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Traditionally, the central nervous system was thought to lack a lymphatic system; however, research over the past decade has overturned this view. Studies have revealed the existence of GS and meningeal lymphatic vessels (mLVs) in the brain, which clear metabolic waste (such as amyloid\u2010\u03b2 and tau proteins) through the exchange of cerebrospinal fluid (CSF) and interstitial fluid (ISF). Dysfunction of the GS can lead to abnormal deposition of pathological proteins, which may trigger or exacerbate AD. Currently, the association between the GS and AD treatment mainly focuses on drug development (such as small molecules that promote glymphatic circulation), physical therapies (such as 40\u2009Hz photoacoustic therapy), and surgical interventions (primarily deep cervical lymphatic\u2010vein anastomosis and cranial bone maneuver), all of which are under exploration. With the precision of diagnostic technologies and the targeting of therapeutic methods, future intervention strategies surrounding GS may become a significant breakthrough in overcoming the treatment impasse of AD, bringing new hope to tens of millions of AD patients worldwide.<\/jats:p>","DOI":"10.1111\/acel.70699","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:11:31Z","timestamp":1789042291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels"],"prefix":"10.1111","volume":"25","author":[{"given":"Bingbing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of the Changchun University of Chinese Medicine  Changchun Jilin Province People's Republic of 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