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Accumulating evidence identifies\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) as a key gut microbiota regulator of aging, with its depletion associated with age\u2010related diseases (ARDs), whereas its abundance is enriched in healthy centenarians. This review summarized current evidence linking\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    to aging, examining their causal relationship, the roles of its bioactive derivatives, underlying mechanisms in aging and ARDs, findings from human clinical trials, and challenges in therapeutic translation. Clinically,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    depletion correlated with aging and various ARDs, while its supplementation effectively ameliorated neurodegenerative disorders, metabolic dysfunction, musculoskeletal decline, intestinal barrier dysfunction, and atherosclerosis. Mechanistically,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    and its derivatives (Amuc_1100, Amuc_1409, extracellular vesicles, and metabolites such as SCFAs) exerted anti\u2010aging effects by enhancing intestinal barrier function, maintaining metabolic homeostasis, suppressing chronic inflammation, and modulating immune function, ultimately improving glucolipid metabolism, insulin sensitivity, cognitive function, musculoskeletal health, and vascular health. Emerging clinical trials further demonstrated its translational potential in ameliorating age\u2010related sarcopenia, metabolic dysfunction, and respiratory symptoms. Despite promising preclinical and clinical results, translational applications reserve challenges related to strain heterogeneity, antimicrobial resistance gene transfer risk, biosafety, production stability, and limited clinical validation in elderly populations. Future research should prioritize large\u2010scale clinical trials to establish optimal dosage, safety, and long\u2010term efficacy, while exploring combined microbiota\u2010targeted therapies. Harnessing the diverse benefits of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    may enable novel strategies for promoting healthy aging.\n                  <\/jats:p>","DOI":"10.1111\/acel.70702","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:02:24Z","timestamp":1788519744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Akkermansia muciniphila<\/i>\n                    and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-9536","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Geriatrics Renji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Medicine and Therapeutics, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Niu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai 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