{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:05:41Z","timestamp":1791378341908,"version":"4.3.2"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG068250"],"award-info":[{"award-number":["R01 AG068250"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Age\u2010associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction. In this study, we report that senescent skeletal muscle myoblasts exhibit elevated activity and expression of the enzyme glutaminase (GLS1), which is mediated by p38 MAPK signaling and leads to intracellular urea accumulation that impairs mitochondrial function. Pharmacological inhibition of GLS1 with CB\u2010839 reduced urea levels, restored the expression of electron transport chain (ETC) complexes, and improved mitochondrial function. Consistent with our in\u00a0vitro findings, CB\u2010839 administration to progeroid mice similarly upregulated ETC complexes and enhanced mitochondrial respiratory capacity in skeletal muscle, leading to improved structural integrity and enhanced muscle strength. Together, these findings suggest that targeting glutamine metabolism via GLS1 inhibition may represent a promising therapeutic strategy to ameliorate age\u2010related skeletal muscle decline by restoring mitochondrial health.<\/jats:p>","DOI":"10.1111\/acel.70703","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:42:13Z","timestamp":1791376933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibiting Glutaminase Reverses Senescence\u2010Associated Mitochondrial Dysfunction and Skeletal Muscle Decline"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2080-821X","authenticated-orcid":false,"given":"Hamsa Vardini","family":"Senthil Kumar","sequence":"first","affiliation":[{"name":"Genetics Genomics and Bioinformatics Program University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1987-1749","authenticated-orcid":false,"given":"Debanik","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-8715","authenticated-orcid":false,"given":"Pedro","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University at Buffalo  Buffalo New York USA"},{"name":"Center for Cell, Gene and Tissue Engineering (CGTE) University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-5013","authenticated-orcid":false,"given":"Pihu","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-6424","authenticated-orcid":false,"given":"Shahryar","family":"Shahini","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7061-8777","authenticated-orcid":false,"given":"Sydney","family":"Swedick","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Toftegaard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-0457","authenticated-orcid":false,"given":"Stelios T.","family":"Andreadis","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University at Buffalo  Buffalo New York USA"},{"name":"Center for Cell, Gene and Tissue Engineering (CGTE) University at Buffalo  Buffalo New York USA"},{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"},{"name":"Center of Excellence in Bioinformatics and Life Sciences University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1038\/s41598-018-26944-x","article-title":"Mitochondrial Function Is Impaired in the Skeletal Muscle of Pre\u2010Frail Elderly","volume":"8","author":"Andreux P. A.","year":"2018","journal-title":"Scientific Reports"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11357-020-00183-3","article-title":"Regulation of Senescence Traits by MAPKs","volume":"42","author":"Anerillas C.","year":"2020","journal-title":"Geroscience"},{"issue":"18","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186480","article-title":"p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?","volume":"21","author":"Bengal E.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ana.410430212","article-title":"Role of Mitochondrial DNA Mutations in Human Aging: Implications for the Central Nervous System and Muscle","volume":"43","author":"Brierley E. J.","year":"1998","journal-title":"Annals of Neurology"},{"issue":"3","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1515\/hsz-2012-0247","article-title":"Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy","volume":"394","author":"Calvani R.","year":"2013","journal-title":"Biological Chemistry"},{"issue":"12","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028090","article-title":"Striking Denervation of Neuromuscular Junctions Without Lumbar Motoneuron Loss in Geriatric Mouse Muscle","volume":"6","author":"Chai R. J.","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12967-023-04369-z","article-title":"Mitochondrial Dysfunction: Roles in Skeletal Muscle Atrophy","volume":"21","author":"Chen X.","year":"2023","journal-title":"Journal of Translational Medicine"},{"issue":"9","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111744","article-title":"Inhibition of Glutaminolysis Restores Mitochondrial Function in Senescent Stem Cells","volume":"41","author":"Choudhury D.","year":"2022","journal-title":"Cell Reports"},{"issue":"2","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113738","article-title":"Proline Restores Mitochondrial Function and Reverses Aging Hallmarks in Senescent Cells","volume":"43","author":"Choudhury D.","year":"2024","journal-title":"Cell Reports"},{"issue":"4","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/gerona\/gls196","article-title":"Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults","volume":"68","author":"Coen P. M.","year":"2013","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"issue":"10","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.mad.2004.07.010","article-title":"Replicative Senescence: A Critical Review","volume":"125","author":"Cristofalo V. J.","year":"2004","journal-title":"Mechanisms of Ageing and Development"},{"issue":"11","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111564","article-title":"Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation","volume":"10","author":"Cruzat V.","year":"2018","journal-title":"Nutrients"},{"issue":"10191","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz\u2010Jentoft A. J.","year":"2019","journal-title":"Lancet"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.01045","article-title":"The Role of Inflammation in Age\u2010Related Sarcopenia","volume":"8","author":"Dalle S.","year":"2017","journal-title":"Frontiers in Physiology"},{"issue":"4","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.1152\/ajpendo.00343.2001","article-title":"Mitochondrial Biogenesis During Skeletal Muscle Regeneration","volume":"282","author":"Duguez S.","year":"2002","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10522-007-9121-7","article-title":"The Role of Mitochondria in Aging of Skeletal Muscle","volume":"9","author":"Figueiredo P. A.","year":"2008","journal-title":"Biogerontology"},{"issue":"1","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/gerona\/gln048","article-title":"Aging Impairs Skeletal Muscle Mitochondrial Bioenergetic Function","volume":"64","author":"Figueiredo P. A.","year":"2009","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"issue":"7","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/CIRCRESAHA.118.312204","article-title":"Mouse Models to Disentangle the Hallmarks of Human Aging","volume":"123","author":"Folgueras A. R.","year":"2018","journal-title":"Circulation Research"},{"issue":"3","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/1874609811104030279","article-title":"Aging Changes in Satellite Cells and Their Functions","volume":"4","author":"Hikida R. S.","year":"2011","journal-title":"Current Aging Science"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2018.11.005","article-title":"Mitochondrial Dysfunction Induces Muscle Atrophy During Prolonged Inactivity: A Review of the Causes and Effects","volume":"662","author":"Hyatt H.","year":"2019","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"2","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2014.05.013","article-title":"Crosstalk Between Mitogen\u2010Activated Protein Kinases and Mitochondria in Cardiac Diseases: Therapeutic Perspectives","volume":"144","author":"Javadov S.","year":"2014","journal-title":"Pharmacology & Therapeutics"},{"issue":"6526","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by Glutaminolysis Inhibition Ameliorates Various Age\u2010Associated Disorders","volume":"371","author":"Johmura Y.","year":"2021","journal-title":"Science"},{"issue":"5","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/ajcn\/nqz191","article-title":"Short\u2010Term Dietary Reduction of Branched\u2010Chain Amino Acids Reduces Meal\u2010Induced Insulin Secretion and Modifies Microbiome Composition in Type 2 Diabetes: A Randomized Controlled Crossover Trial","volume":"110","author":"Karusheva Y.","year":"2019","journal-title":"American Journal of Clinical Nutrition"},{"issue":"12","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050390","article-title":"Glutamine Supplementation Stimulates Protein\u2010Synthetic and Inhibits Protein\u2010Degradative Signaling Pathways in Skeletal Muscle of Diabetic Rats","volume":"7","author":"Lambertucci A. C.","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging\u2010Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson L.","year":"2019","journal-title":"Physiological Reviews"},{"issue":"13","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial Dysfunction in Cell Senescence and Aging","volume":"132","author":"Miwa S.","year":"2022","journal-title":"Journal of Clinical Investigation"},{"issue":"7942","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-022-05535-x","article-title":"Senescence Atlas Reveals an Aged\u2010Like Inflamed Niche That Blunts Muscle Regeneration","volume":"613","author":"Moiseeva V.","year":"2023","journal-title":"Nature"},{"issue":"5","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.exger.2013.02.012","article-title":"The Decline in Skeletal Muscle Mass With Aging Is Mainly Attributed to a Reduction in Type II Muscle Fiber Size","volume":"48","author":"Nilwik R.","year":"2013","journal-title":"Experimental Gerontology"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122324","article-title":"The Contribution of Mitochondria to Age\u2010Related Skeletal Muscle Wasting: A Sex\u2010Specific Perspective","volume":"336","author":"Nuccio A.","year":"2024","journal-title":"Life Sciences"},{"issue":"7","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In Vivo Amelioration of Age\u2010Associated Hallmarks by Partial Reprogramming","volume":"167","author":"Ocampo A.","year":"2016","journal-title":"Cell"},{"key":"e_1_2_10_32_1","first-page":"12(2)","article-title":"Age\u2010Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia","volume":"12","author":"Paez H. G.","year":"2023","journal-title":"Cells"},{"issue":"2","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14039","article-title":"Partial Cellular Reprogramming: A Deep Dive Into an Emerging Rejuvenation Technology","volume":"23","author":"Paine P. T.","year":"2024","journal-title":"Aging Cell"},{"issue":"22","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228844","article-title":"Sarcopenia: Molecular Pathways and Potential Targets for Intervention","volume":"21","author":"Pascual\u2010Fernandez J.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0891-5849(01)00517-2","article-title":"Age\u2010Related Mitochondrial Genotypic and Phenotypic Alterations in Human Skeletal Muscle","volume":"30","author":"Pesce V.","year":"2001","journal-title":"Free Radical Biology & Medicine"},{"issue":"4","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jshs.2013.07.001","article-title":"Human Neuromuscular Structure and Function in Old Age: A Brief Review","volume":"2","author":"Power G. A.","year":"2013","journal-title":"Journal of Sport and Health Science"},{"issue":"3","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13764","article-title":"Reversine Ameliorates Hallmarks of Cellular Senescence in Human Skeletal Myoblasts via Reactivation of Autophagy","volume":"22","author":"Rajabian N.","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41467-023-36483-3","article-title":"Methionine adenosyltransferase2A Inhibition Restores Metabolism to Improve Regenerative Capacity and Strength of Aged Skeletal Muscle","volume":"14","author":"Rajabian N.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2016.04.002","article-title":"The Relationship Between Mitochondrial Function and Walking Performance in Older Adults With a Wide Range of Physical Function","volume":"81","author":"Santanasto A. J.","year":"2016","journal-title":"Experimental Gerontology"},{"issue":"36","key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe5671","article-title":"Ameliorating the Hallmarks of Cellular Senescence in Skeletal Muscle Myogenic Progenitors In\u00a0Vitro and In\u00a0Vivo","volume":"7","author":"Shahini A.","year":"2021","journal-title":"Science Advances"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.scr.2018.05.017","article-title":"Efficient and High Yield Isolation of Myoblasts From Skeletal Muscle","volume":"30","author":"Shahini A.","year":"2018","journal-title":"Stem Cell Research"},{"issue":"15","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.0501559102","article-title":"Decline in Skeletal Muscle Mitochondrial Function With Aging in Humans","volume":"102","author":"Short K. R.","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6649","key":"e_1_2_10_43_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn9257","article-title":"Taurine Deficiency as a Driver of Aging","volume":"380","author":"Singh P.","year":"2023","journal-title":"Science"},{"issue":"1","key":"e_1_2_10_44_1","first-page":"53","article-title":"New Look at the Role of Progerin in Skin Aging","volume":"14","author":"Skoczynska A.","year":"2015","journal-title":"Przeglad Menopauzalny"},{"issue":"6","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/07853890600888413","article-title":"The Metabolic Syndrome: Role of Skeletal Muscle Metabolism","volume":"38","author":"Stump C. S.","year":"2006","journal-title":"Annals of Medicine"},{"issue":"2","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13552","article-title":"Muscle Mitochondrial Energetics Predicts Mobility Decline in Well\u2010Functioning Older Adults: The Baltimore Longitudinal Study of Aging","volume":"21","author":"Tian Q.","year":"2022","journal-title":"Aging Cell"},{"issue":"8","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and Molecular Mechanisms of Stress\u2010Induced Premature Senescence (SIPS) of Human Diploid Fibroblasts and Melanocytes","volume":"35","author":"Toussaint O.","year":"2000","journal-title":"Experimental Gerontology"},{"issue":"6","key":"e_1_2_10_48_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13626","article-title":"Protein Restriction and Branched\u2010Chain Amino Acid Restriction Promote Geroprotective Shifts in Metabolism","volume":"21","author":"Trautman M. E.","year":"2022","journal-title":"Aging Cell"},{"issue":"11","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/gerona\/glu096","article-title":"Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community\u2010Dwelling Older Adults","volume":"70","author":"Tyrrell D. J.","year":"2015","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-62703-556-9_11","article-title":"Methods of Cellular Senescence Induction Using Oxidative Stress","volume":"1048","author":"Wang Z.","year":"2013","journal-title":"Methods in Molecular Biology"},{"issue":"14","key":"e_1_2_10_51_1","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00659-16","article-title":"Progerin\u2010Induced Replication Stress Facilitates Premature Senescence in Hutchinson\u2010Gilford Progeria Syndrome","volume":"37","author":"Wheaton K.","year":"2017","journal-title":"Molecular and Cellular Biology"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2020.12.038","article-title":"Glutaminase Inhibition With Telaglenastat (CB\u2010839) Improves Treatment Response in Combination With Ionizing Radiation in Head and Neck Squamous Cell Carcinoma Models","volume":"502","author":"Wicker C. A.","year":"2021","journal-title":"Cancer Letters"},{"issue":"6","key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4196\/kjpp.2018.22.6.697","article-title":"Mitochondrial Dysfunction Reduces the Activity of KIR2.1 K+ Channel in Myoblasts via Impaired Oxidative Phosphorylation","volume":"22","author":"Woo J.","year":"2018","journal-title":"Korean Journal of Physiology & Pharmacology"},{"key":"e_1_2_10_54_1","article-title":"Age\u2010 and Gender\u2010Based Differences in Nest\u2010Building Behavior and Learning and Memory Performance Measured Using a Radial Six\u2010Armed Water Maze in C57BL\/6 Mice","volume":"2018","author":"Xiong X. D.","year":"2018","journal-title":"Behavioral Neurology"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-bioeng-071516-044546","article-title":"Glutaminolysis: A Hallmark of Cancer Metabolism","volume":"19","author":"Yang L.","year":"2017","journal-title":"Annual Review of Biomedical Engineering"},{"issue":"1","key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1038\/s41598-018-26632-w","article-title":"Targeted Ablation of p38alpha MAPK Suppresses Denervation\u2010Induced Muscle Atrophy","volume":"8","author":"Yuasa K.","year":"2018","journal-title":"Scientific Reports"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110784","article-title":"Long Term Breeding of the Lmna G609G Progeric Mouse: Characterization of Homozygous and Heterozygous Models","volume":"130","author":"Zaghini A.","year":"2020","journal-title":"Experimental Gerontology"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:42:22Z","timestamp":1791376942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/acel.70703"],"URL":"https:\/\/doi.org\/10.1111\/acel.70703","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70703"}}