{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:30Z","timestamp":1790574930701,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA0923301"],"award-info":[{"award-number":["2025YFA0923301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    While immunosenescence is increasingly implicated in chronic inflammatory disorders, its precise pathogenic contribution to ulcerative colitis (UC) remains elusive. Here, we identify senescent CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells as a distinct pathogenic population that exacerbates colitis, demonstrating that systemic senolytic treatment significantly attenuates disease severity. Mechanistically, nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) metabolic dysregulation triggers mitochondrial dysfunction and cytosolic mitochondrial DNA leakage, promoting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell senescence through the activation of the cGAS\u2010STING signaling pathway. Spatial transcriptomic mapping reveals that senescent CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are enriched within mucosal niches experiencing NAD\n                    <jats:sup>+<\/jats:sup>\n                    metabolic dysregulation. Crucially, this senescent\u2010metabolic signature correlates with severe disease phenotypes and predicts non\u2010response to biologic therapies in UC patients. Collectively, our findings uncover a critical NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010cGAS\u2010STING axis driving T cell senescence, establishing the clearance of senescent immune cells as a promising therapeutic strategy for UC.\n                  <\/jats:p>","DOI":"10.1111\/acel.70706","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:30:20Z","timestamp":1789011020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>NAD<\/scp>\n                    <sup>+<\/sup>\n                    Metabolic Reprogramming Drives\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T Cells Senescence and Exacerbates Ulcerative Colitis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-4095","authenticated-orcid":false,"given":"Maolin","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Digestive Diseases Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Huashan Hospital, Fudan University  Shanghai 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