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Beyond this transition, the postmenopausal ovary is often regarded as quiescent and remains poorly characterized. We analyzed the proteomes of healthy, non\u2010pathological ovaries using mass spectrometry (data\u2010independent acquisition) from 28 postmenopausal women (50\u201375\u2009years old), stratified into three age groups (50\u201359, 60\u201369, \u2265\u200970). We quantified 5812 protein groups and observed progressive age\u2010associated shifts, with 117 proteins significantly altered in the \u2265\u200970 versus 50\u201359 age comparison. Multivariate analysis demonstrated clear separation between 50\u201359 and \u2265\u200970\u2010year\u2010old age cohorts, with protein signatures shifting from RNA\/gene\u2010regulatory functions in younger ovaries to metabolic, trafficking, and innate immune\/complement pathways in older ovaries. Across differential abundance, multivariate modeling, and covariate\u2010adjusted linear modeling, we identified a convergent set of age\u2010associated proteins that were integrated into the 26\u2010protein\n                    <jats:styled-content>\n                      <jats:bold>B<\/jats:bold>\n                    <\/jats:styled-content>\n                    <jats:styled-content>\n                      <jats:bold>uck<\/jats:bold>\n                    <\/jats:styled-content>\n                    <jats:styled-content>\n                      <jats:bold>P<\/jats:bold>\n                    <\/jats:styled-content>\n                    ostmenopausal\n                    <jats:styled-content>\n                      <jats:bold>O<\/jats:bold>\n                    <\/jats:styled-content>\n                    vary\n                    <jats:styled-content>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:styled-content>\n                    olecular\n                    <jats:styled-content>\n                      <jats:bold>S<\/jats:bold>\n                    <\/jats:styled-content>\n                    ignature (BuckPOMS), a consensus molecular signature capturing progressive extracellular matrix remodeling, inflammatory signaling, and loss of structural and keratin\u2010associated proteins with age. Representative BuckPOMS proteins, including the secreted matrisome proteins WNT4 and Fibromodulin (FMOD), were validated by immunohistochemistry. Pathway enrichment further identified an increase in inflammatory and matrisome pathways, and increased abundance of damage\u2010associated secretory factors decades following menopause. These data fundamentally shift the notion of the postmenopausal ovary as an inert organ and instead demonstrate active and continuous molecular remodeling that has potential relevance to tissue signaling and implications for women's health.\n                  <\/jats:p>","DOI":"10.1111\/acel.70714","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:00:17Z","timestamp":1791954017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Human Ovary Exhibits Dynamic Molecular Remodeling in the Decades Post\u2010Menopause"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-4457","authenticated-orcid":false,"given":"Mark A.","family":"Watson","sequence":"first","affiliation":[{"name":"Buck Institute for Research on Aging  Novato California 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