{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:45:40Z","timestamp":1792611940816,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mitochondrial quality control is severely impaired in the aging heart, largely attributed to disrupted mitophagy homeostasis. However, the key molecular drivers remain poorly defined, and the translational value of mitochondria\u2010targeted therapy for cardiac aging is still underexplored. Here, we report prominent mitophagy flux congestion in aged cardiac tissue and confirm that mitochondrial transplantation efficiently rescues impaired mitophagy, ultimately rejuvenating the aging heart. Mechanistically, we identify a novel HIF\u20103\u03b1\u2010BNIP3 signaling axis in the aging heart: HIF\u20103\u03b1, conventionally recognized as a transcriptional repressor, is aberrantly upregulated in senescent cardiomyocytes and directly regulates excessive BNIP3 expression to trigger mitophagy congestion. Notably, we establish an innovative translational strategy that mitochondrial transplantation restrains pathological overactivation of the HIF\u20103\u03b1\u2010BNIP3 axis via improving intracellular ATP homeostasis, thereby reconstructing normal mitophagy flux and reversing cardiac aging. Our findings uncover an unrecognized upstream regulator of age\u2010related mitophagy defects and provide a mitochondrial\u2010based intervention approach for the treatment of aging\u2010associated cardiac dysfunction.<\/jats:p>","DOI":"10.1111\/acel.70720","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:19:08Z","timestamp":1790162348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the\n                    <scp>HIF<\/scp>\n                    \u20103\u03b1\u2010\n                    <scp>BNIP3<\/scp>\n                    Axis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4864-3043","authenticated-orcid":false,"given":"Ning","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key 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Pathogenicity and Prevention (Shanxi Medical University) Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University) Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6633-9866","authenticated-orcid":false,"given":"Xiaozhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University) Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University) Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical University  Taiyuan 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