{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:45:07Z","timestamp":1792611907443,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3500300"],"award-info":[{"award-number":["2022YFC3500300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3500305"],"award-info":[{"award-number":["2022YFC3500305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging is often associated with intestinal microbiota imbalance and immune system degeneration. The dysregulation and crosstalk of these two factors markedly elevate the elderly's susceptibility to infections and age\u2010related diseases.\n                    <jats:italic>Polygonatum odoratum<\/jats:italic>\n                    , a traditional Chinese medicinal herb, is widely used in geriatric care for its lung\u2010moistening and nourishing effects. However, its potential regulatory roles on the microbiota and immunity in the aging context remain unreported. A total of 140 independently living elderly individuals aged 60 and above were recruited for this study. The randomized, double\u2010blinded study including YZG (\n                    <jats:italic>P. odoratum<\/jats:italic>\n                    ) and placebo groups was performed for 90\u2009days' intervention. Peripheral blood immune cell subsets were analyzed by flow cytometry, and microbial diversity in fecal samples was assessed by 16S rRNA sequencing. Baseline correlation analysis revealed that alterations in gut microbiota were predominantly associated with T cell subsets. Specifically,\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    showed a significant negative correlation with age\u2010related memory T cells, including CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    TEMRA. Additionally,\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    exhibited a significant positive correlation with partial subsets of CD4\n                    <jats:sup>+<\/jats:sup>\n                    TEMRA. After 90\u2010day YZG intervention, the percentage of TEMRA and CD28\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD57\n                    <jats:sup>+<\/jats:sup>\n                    TEMRA cells were reduced in elderly subjects. The relative abundance of\n                    <jats:italic>Prevotella 9<\/jats:italic>\n                    and\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    were increased, and the abundance of\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    in the gut microbiota were significantly decreased. Correlation analysis linked YZG\u2010induced gut microbiota changes to improved immunity and fewer respiratory infections. This study demonstrates significant correlations that exist between immunosenescence in T\u2010cell compartments and gut microbial composition, suggesting a potential interplay between microbial health and immune aging.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    UMIN Clinical Trials Registry identifier: UMIN000052572\n                  <\/jats:p>","DOI":"10.1111\/acel.70724","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:24:42Z","timestamp":1790162682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Gut Microbiota and Immune Profiles in Community\u2010Dwelling Older Adults and the Regulatory Role of\n                    <i>Polygonatum odoratum<\/i>"],"prefix":"10.1111","volume":"25","author":[{"given":"Tingting","family":"Xia","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Cui","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-2427","authenticated-orcid":false,"given":"Yuhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Preventive Treatment Department Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1538-5251","authenticated-orcid":false,"given":"Shengyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Preventive Treatment Department Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiuzhitang Co. Ltd  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglan","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiuzhitang Co. Ltd  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health UT Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-7975","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Cui","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"An","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-091X","authenticated-orcid":false,"given":"Xinqin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  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