{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:44:49Z","timestamp":1792611889255,"version":"4.5.0"},"reference-count":400,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mitochondria play a crucial role in cellular energy metabolism. The heart and brain require a continuous and stable energy supply. Energy production strongly depends on proper mitochondrial function. Mitochondrial fusion and fission, known as \u201cplasticity\u201d, are vital for maintaining the normal physiological function of cells. Recent studies have shown that impaired mitochondrial dynamics are present in many aging\u2010related diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and atherosclerotic cardio\u2010cerebrovascular disease. The role of impaired mitochondrial dynamics in the pathophysiological process of aging\u2010related diseases is being actively researched. We discovered that targeting proteins related to mitochondrial dynamics, especially those involved in fission and fusion, may offer new treatment strategies for these diseases. Various approaches, including aerobic interval and treadmill training and the use of drugs such as the antidiabetic agents metformin and dapagliflozin, the antihypertensive agent irbesartan, and certain traditional Chinese medicine components, have shown potential in alleviating imbalances in mitochondrial dynamics in aging\u2010related cardio\u2010cerebrovascular diseases. In this review, we systematically summarize recent research on alterations in mitochondrial dynamics in age\u2010related cardio\u2010cerebral diseases and explore therapeutic strategies targeting these alterations, which may offer new directions for improving cardiac and brain health and guiding clinical practice.<\/jats:p>","DOI":"10.1111\/acel.70729","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:18:03Z","timestamp":1790162283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Fusion and Fission in Age\u2010Related Cardio\u2010Cerebral Diseases: Mechanisms and Interventions"],"prefix":"10.1111","volume":"25","author":[{"given":"Yuyao","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Cardiology Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-9622","authenticated-orcid":false,"given":"Zijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Shengjing Hospital of China Medical University  Shenyang Liaoning 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