{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:02:15Z","timestamp":1790751735510,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025496234"],"award-info":[{"award-number":["RS\u20102026\u201025496234"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025509438"],"award-info":[{"award-number":["RS\u20102026\u201025509438"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025514886"],"award-info":[{"award-number":["RS\u20102026\u201025514886"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CRC22015\u2010200"],"award-info":[{"award-number":["CRC22015\u2010200"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Skeletal muscle aging is increasingly recognized as a failure of tissue\u2010level coordination rather than a consequence of isolated defects in individual cell types. Recent advances in single\u2010cell, spatial, and multimodal omics have revealed that aging remodels the abundance, functional states, and interactions of muscle\u2010resident populations, shifting the tissue from a regenerative niche toward a degenerative niche. In this Review, we summarize current evidence supporting this conceptual transition by focusing on multicellular crosstalk and population dynamics within the aging muscle microenvironment. We discuss how age\u2010dependent remodeling of muscle stem cells, fibro\u2010adipogenic progenitors, immune cells, vascular cells, and neuromuscular components collectively disrupts the temporal coordination required for effective regeneration. Rather than acting independently, these populations become locked in maladaptive signaling circuits that promote persistent inflammation, fibrosis, senescence, impaired vascular support, and neuromuscular dysfunction, ultimately compromising tissue repair and muscle function. We further distinguish ligand\u2010receptor interactions inferred from single\u2010cell atlases from signaling pathways that have been functionally validated in\u00a0vivo, highlighting the importance of establishing causal mechanisms underlying intercellular communication. Finally, we discuss emerging therapeutic strategies aimed at restoring multicellular coordination\u2014including modulation of stromal, immune, vascular, and neuromuscular interactions\u2014rather than targeting single cell populations in isolation. We propose that rebuilding regenerative communication networks, instead of simply eliminating dysfunctional cells, represents a promising framework for developing interventions against sarcopenia and age\u2010related muscle decline.<\/jats:p>","DOI":"10.1111\/acel.70733","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:40:46Z","timestamp":1790750446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8555-8431","authenticated-orcid":false,"given":"Seongwan","family":"Kim","sequence":"first","affiliation":[{"name":"Aging Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  Daejeon Republic of Korea"},{"name":"Department of Bio\u2010Molecular Science, KRIBB School of Bioscience Korea University of Science and Technology (UST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-4407","authenticated-orcid":false,"given":"Min Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Aging Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9096-7420","authenticated-orcid":false,"given":"Yong Ryoul","family":"Yang","sequence":"additional","affiliation":[{"name":"Aging Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  Daejeon Republic of Korea"},{"name":"Department of Bio\u2010Molecular Science, KRIBB School of Bioscience Korea University of Science and Technology (UST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.12.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111974"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201035547\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128248"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11061017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u20100190\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2026.03.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u20100186\u20109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.964130"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091214"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.067"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010023\u201009904\u20106"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00354.2010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010021\u201000215\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111595"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.10.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.198"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0708"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00208"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202300134"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038624\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20230319"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101319"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158058"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201005096\u2010w"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads9175"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27158"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2023.05.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007348\u20106"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111445119"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036265\u2010x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4126"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.12.014"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201002810\u2010x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201091094\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010021\u201000927\u2010z"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005535\u2010x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.952041"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4989"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.10.009"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106156"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804149115"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00416.2017"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16352"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.03.006"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114975"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103125"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13312"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139617"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000756\u20103"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.033"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005142\u20108"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/load012"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010024\u201000433\u20104"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14069"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063265"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:40:48Z","timestamp":1790750448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/acel.70733"],"URL":"https:\/\/doi.org\/10.1111\/acel.70733","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70733"}}