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While age\u2010related differences in cardiac remodeling and healing post MI are well\u2010documented clinically, appropriate pre\u2010clinical studies are needed to evaluate the underlying pathological mechanisms and to further improve therapeutic interventions. Here, we compared LV remodeling between young and aged C57BL\/6 mice, following permanent LAD ligation, using CMR imaging after 2, 7, and 28\u2009days of MI induction. At baseline conditions, aged mice exhibited higher end\u2010diastolic and end\u2010systolic volumes and tended to have a reduced deformation capacity. Post\u2010MI, both groups showed significant LV dilation, loss of contractility, and impaired ejection fraction. Interestingly, young mice undergo larger proportional geometric changes relative to their pre\u2010infarction state. At the same time, histological data of labeled heart sections pointed to a more rapid healing process in young animals. These findings highlight the critical role of age in modulating cardiac remodeling and, thus, challenge the commonly held hypothesis of an age\u2010dependent increase of LV remodeling.<\/jats:p>","DOI":"10.1111\/acel.70748","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:00Z","timestamp":1790836740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Young Mice Exhibit Increased Relative Ventricular Remodeling After\n                    <scp>AMI<\/scp>\n                    \u2014A Longitudinal\n                    <scp>CMR<\/scp>\n                    Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-2323","authenticated-orcid":false,"given":"Heiko","family":"Lemcke","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"W\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-1171","authenticated-orcid":false,"given":"Antonia","family":"Dalmer","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"G\u00e4bel","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock 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Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Lindner","sequence":"additional","affiliation":[{"name":"Core Facility Multimodal Small Animal Imaging University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd Joachim","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Rudolf\u2010Zenker\u2010Institute for Experimental Surgery Rostock University Medical Center  Rostock 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