{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:51:27Z","timestamp":1791539487399,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early\u2010life nutrition may influence long\u2010term health, but its impact on organ\u2010specific biological aging is unclear. We investigated associations of birthweight and breastfeeding with multi\u2010organ aging and potential mediating pathways in adulthood. Using UK Biobank data, we examined associations of retrospectively reported birthweight (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921,446) and breastfeeding history (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929,713) with 19 proteomics\u2010derived aging indices, comprising 18 organ\u2010specific indices and one composite index. Multivariable linear regression assessed individual and joint associations, effect modification by sex and socioeconomic factors, and mediation by allostatic load (AL) and C\u2010reactive protein (CRP). Higher birthweight was inversely associated with aging across 11 organ systems (all FDR\u2010adjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with strongest associations in the intestine (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.069), esophagus (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.055), and stomach (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.053). Breastfeeding exposure was associated with slower aging of the intestine (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.047) and adrenal gland (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.030), but modestly faster thyroid aging (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.033). The combination of higher birthweight and breastfeeding was associated with favorable aging profiles, particularly in the intestine (\u03b2\u2009=\u2009\u22120.13), stomach (\u03b2\u2009=\u2009\u22120.09), and kidney (\u03b2\u2009=\u2009\u22120.08). Associations were stronger among females and socioeconomically advantaged or healthier\u2010behavior subgroups. AL mediated up to 35.3% of the birthweight\u2013aging association, whereas CRP showed minimal mediation. Higher birthweight and breastfeeding, particularly in combination, produce the most favorable profiles of multi\u2010organ biological aging in adulthood, with AL partially mediating these effects. These findings provide novel evidence that prenatal and postnatal nutrition leave enduring, system\u2010wide imprints on adult aging trajectories.\n                  <\/jats:p>","DOI":"10.1111\/acel.70762","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:18:41Z","timestamp":1791537521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Birthweight and Breastfeeding Shape Patterns of Biological Aging Across Adult Organs"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-2732","authenticated-orcid":false,"given":"Wenming","family":"Wei","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Environment and Endemic Diseases, School of Public Health, Health Science Center Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-9567","authenticated-orcid":false,"given":"Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Environment and Endemic Diseases, School of Public Health, Health Science Center Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region  Xi'an Shaanxi China"},{"name":"Precision Medicine Center The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an P. R. 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Endemic Diseases, School of Public Health, Health Science Center Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-0312","authenticated-orcid":false,"given":"Shiqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Environment and Endemic Diseases, School of Public Health, Health Science Center Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuena","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Environment and Endemic Diseases, School of Public Health, Health Science Center Xi'an Jiaotong University  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