{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:45:40Z","timestamp":1792611940709,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hutchinson\u2013Gilford progeria syndrome (HGPS) is a rare premature aging disorder most commonly caused by a de novo synonymous mutation (c.1824C&gt;T) in the\n                    <jats:italic>LMNA<\/jats:italic>\n                    gene. This mutation activates aberrant splicing of prelamin A, leading to the production and accumulation of progerin, which drives accelerated aging, with patients predominantly succumbing to cardiovascular disease. However, while cardiac pathologies are well documented, the cell\u2010autonomous contribution of cardiomyocytes to HGPS\u2010associated cardiac remodeling remains poorly understood. Here, we generated a cardiomyocyte\u2010specific progerin\u2010expressing mouse model (\n                    <jats:italic>Myh6<\/jats:italic>\n                    \u2010Cre;\n                    <jats:italic>Lmna<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    ) and found that selective progerin expression in cardiomyocytes was sufficient to recapitulate key cardiac features of HGPS, including myocardial fibrosis, cardiac hypertrophy, and progressive functional decline. Mechanistically, progerin\u2010expressing hearts exhibited a marked reduction in the N\n                    <jats:sup>6<\/jats:sup>\n                    \u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) writer components METTL3\/14, and knockdown of\n                    <jats:italic>Mettl3\/14<\/jats:italic>\n                    in primary cardiomyocytes decreased the expression of calcium\u2010handling transcript (\n                    <jats:italic>Casq2<\/jats:italic>\n                    ), while elevating senescence\u2010related (\n                    <jats:italic>Cdkn1a<\/jats:italic>\n                    and\n                    <jats:italic>Cdkn2a<\/jats:italic>\n                    ) and pro\u2010inflammatory transcripts (\n                    <jats:italic>Ifna<\/jats:italic>\n                    and\n                    <jats:italic>Ifnb<\/jats:italic>\n                    ). Importantly, cardiomyocyte\u2010targeted restoration of METTL14 partially ameliorated pathological cardiac remodeling and dysfunction in progeroid mice. Together, the data identify METTL14\u2010dependent m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation as a critical regulator of cardiomyocyte integrity during progeria\u2010associated cardiac remodeling. Restoration of cardiac m\n                    <jats:sup>6<\/jats:sup>\n                    A writer activity may represent a potential therapeutic strategy for laminopathy\u2010related cardiovascular aging.\n                  <\/jats:p>","DOI":"10.1111\/acel.70765","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:01:18Z","timestamp":1792062078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>METTL14<\/scp>\n                    \u2010Mediated\n                    <scp>\n                      m\n                      <sup>6<\/sup>\n                      A\n                    <\/scp>\n                    Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria\u2010Associated Cardiac Remodeling"],"prefix":"10.1111","volume":"25","author":[{"given":"Shixiao","family":"Wang","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"},{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4449-872X","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"},{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National\u2014Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4091-6088","authenticated-orcid":false,"given":"Ying","family":"Ao","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"},{"name":"Shenzhen Key Laboratory of Cell Senescence and Regeneration Innovation, School of Basic Medical Sciences Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9150-0415","authenticated-orcid":false,"given":"Dan","family":"Rao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Yu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"},{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-1063","authenticated-orcid":false,"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Wannan Medical University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingying","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"},{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Mei","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6115-0968","authenticated-orcid":false,"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"},{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanli","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Xi\u2010Jing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-3821","authenticated-orcid":false,"given":"Zimei","family":"Wang","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"},{"name":"Shenzhen Key Laboratory of Cell Senescence and Regeneration Innovation, School of Basic Medical Sciences Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-1286","authenticated-orcid":false,"given":"Wen","family":"Su","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"},{"name":"Shenzhen Key Laboratory of Cell Senescence and Regeneration Innovation, School of Basic Medical Sciences Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-8059","authenticated-orcid":false,"given":"Baohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL\u2010SAI), School of Basic Medical Sciences, Shenzhen University  Shenzhen China"},{"name":"National Health Commission Key Laboratory of Bone Aging Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.69094"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100492"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1672"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309200120"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.116"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2010.00581.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(72)80229\u20104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036146"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01629"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261417"},{"key":"e_1_2_10_13_1","volume-title":"Hutchinson\u2010Gilford 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