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During aging, muscle\u2010derived EVs have emerged as important mediators of interorgan communication, influencing tissue homeostasis, regeneration, metabolism, and disease progression. Recent studies demonstrate that skeletal muscle EVs carry diverse cargos such as proteins, lipids, metabolites, and regulatory RNAs that can modulate the function of recipient cells in multiple organs. In particular, aging\u2010associated alterations in EV biogenesis, cargo composition, and secretion may contribute to chronic inflammation, stem cell dysfunction, metabolic decline, and age\u2010related pathologies. In this review, we summarize current advances in skeletal muscle\u2010derived EV biology and their roles in interorgan communication during aging. We discuss mechanisms regulating EV formation and cargo loading, their impact on stem cell function and tissue regeneration, and their involvement in aging\u2010related diseases. We also highlight the translational potential of muscle EVs as biomarkers and therapeutic targets. Together, these findings identify muscle\u2010derived EVs as key regulators of systemic aging and interorgan signaling.<\/jats:p>","DOI":"10.1111\/acel.70773","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:46:50Z","timestamp":1792050410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skeletal Muscle\u2010Derived Extracellular Vesicles in Interorgan Communication During Aging"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0900-1437","authenticated-orcid":false,"given":"Weiyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Program in Cancer and Stem Cell Biology Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenon","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Singapore General Hospital  Singapore 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