{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:42:39Z","timestamp":1778647359087,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Topical skin adhesives (<jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>s) offer a noninvasive alternative to sutures. The growing trend is to use them in addition to sutures and staples to add strength and provide a microbial barrier. The authors compared the mechanical characteristics of recently approved <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>s that are most likely to be of surgical relevance in the emergency department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Linear incisions were made on anesthetized swine and the wounds were approximated with one of six commercially available <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>s. Three\u2010dimensional bursting strength was measured with a <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\u20102000<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> device. Tensile failure force was measured ex vivo using <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>\u2010approximated porcine skin strips with a tensionometer. Resistance to cyclic loading was measured by subjecting approximated skin strips to repetitive cycles of rotational torque and linear tension. Viscosity was measured with a viscometer and setting times were measured by periodically dabbing the adhesive applied to skin strips with a cotton swab to determine whether it was dry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermabond Advanced <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content> provided significantly (p\u00a0&lt;\u00a00.00001) greater acute in vivo wound bursting strength and ex vivo tensile force, greater mean number of normal tensile loading cycles to failure (while under continuous torsional cycling), and longest time to failure, and the mean setting time was the shortest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Of all the <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>s tested in this study, Dermabond Advanced was the strongest and most flexible, set in the shortest time, and was a fairly viscous adhesive, all of which are clinically desirable characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12009","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T22:22:39Z","timestamp":1353450159000},"page":"1281-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives"],"prefix":"10.1111","volume":"19","author":[{"given":"Adam J.","family":"Singer","sequence":"first","affiliation":[{"name":"From the Department of Emergency Medicine Stony Brook University Stony Brook NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Perry","sequence":"additional","affiliation":[{"name":"Pluris Research Inc. Franklin TN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.05.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.121377"},{"key":"e_1_2_7_4_1","volume-title":"An Evaluation of Acute Incisional Strength With TraumaSeal Surgical Tissue Adhesive Wound Closure","author":"Perry LC","year":"1995"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2008.00273.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2008.10.009"},{"key":"e_1_2_7_7_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Institutes of Health","year":"1996"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2001.00066.x"},{"key":"e_1_2_7_9_1","first-page":"37","volume-title":"Methods in Molecular Medicine, vol 78: Wound Healing: Methods and Protocols","author":"Gamelli RL","year":"2003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/10962960260496370"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1999.tb00151.x"},{"key":"e_1_2_7_12_1","first-page":"409","article-title":"Histoacryl vs Dermabond cyanoacrylate glue for closing small operative wounds","volume":"139","author":"Steiner Z","year":"2000","journal-title":"Harefuah."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.04.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.06.015"}],"container-title":["Academic Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facem.12009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acem.12009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:13:59Z","timestamp":1698714839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acem.12009"}},"subtitle":[],"editor":[{"given":"Shahriar","family":"Zehtabchi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/acem.12009"],"URL":"https:\/\/doi.org\/10.1111\/acem.12009","archive":["Portico"],"relation":{},"ISSN":["1069-6563","1553-2712"],"issn-type":[{"value":"1069-6563","type":"print"},{"value":"1553-2712","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"2012-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}