{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:15:06Z","timestamp":1787591706005,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Radiocontrast nephropathy (<jats:styled-content style=\"fixed-case\">RCN<\/jats:styled-content>) is a known complication of procedures in which intravascular iodinated contrast material is used. The authors sought to determine the risk factors for <jats:styled-content style=\"fixed-case\">RCN<\/jats:styled-content> after emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) contrast\u2010enhanced computerized tomography (<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case\u2013control study of patients presenting to a tertiary care ED between January 1, 2004, and December 31, 2006. Inclusion criteria were CECT performed in the ED, serum creatinine measured prior to CECT, and serum creatinine measured 48 to 96\u00a0hours after CECT. Exclusion criterion was dialysis\u2010dependent renal failure prior to CECT. The outcome of RCN was defined as an absolute creatinine increase of greater than or equal to 0.5\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, or a 25% increase above baseline. The charts of all RCN patients and a random sample of non\u2010RCN patients were reviewed to document the presence or absence of potential risk factors. Univariate analysis was performed using chi\u2010square and multiple logistic regression applying a weighted technique to account for sampling of non\u2010RCN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 5,006 patients meeting inclusion criteria, 349 (7%) developed RCN. Multiple regression analysis demonstrated that serum creatinine &gt; 2\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, liver disease, heart failure, hematocrit &lt;\u00a030%, hypertension, and diabetes were risk factors for RCN, whereas age\u00a0&gt;\u00a075\u00a0years, vascular disease, and serum creatinine &gt; 1.5\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> were not. The area under the curve (AUC) for the model was 0.65. Although the risk of RCN increased with the number of risk factors present, we could not develop a model with sufficient diagnostic accuracy to guide clinical decision\u2010making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The authors report risk factors for <jats:styled-content style=\"fixed-case\">RCN<\/jats:styled-content> in a large case\u2013control study, but could not develop an accurate decision tool to identify patients at increased risk for <jats:styled-content style=\"fixed-case\">RCN<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ED CECT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12059","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T01:30:31Z","timestamp":1358127031000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Risk Factors for Radiocontrast Nephropathy After Emergency Department Contrast\u2010enhanced Computerized Tomography"],"prefix":"10.1111","volume":"20","author":[{"given":"Stephen J.","family":"Traub","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Beth Israel Deaconess Medical Center Boston MA"},{"name":"Department of Emergency Medicine Mayo Clinic Arizona Phoenix AZ"},{"name":"Mayo Clinic College of Medicine Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kellum","sequence":"additional","affiliation":[{"name":"CRISMA Center Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Beth Israel Deaconess Medical Center Boston 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