{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:00:10Z","timestamp":1787497210950,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n A novel swine\u2010origin influenza A (H1N1) virus caused worldwide outbreaks starting in April 2009. The aim of this study was to evaluate the clinical characteristics and outcomes of pandemic 2009 H1N1 pneumonia by comparing to community\u2010acquired pneumonia (\n CAP<\/jats:styled-content>\n ) of other origin.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The authors conducted a prospective cohort study of consecutive adult (over 15\u00a0years old) patients with suspected\n CAP<\/jats:styled-content>\n requiring admission to a tertiary university\u2010affiliated hospital during the second wave of pandemic 2009 H1N1 influenza. Based on the results of real\u2010time reverse transcriptase\u2013polymerase chain reaction (\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n ) analysis, the staff completed a standard assessment form and managed the patients according to a uniform protocol. Clinical characteristics, as well as laboratory and radiologic findings, were collected and compared between pandemic 2009 H1N1 pneumonia and\n CAP<\/jats:styled-content>\n of other origin. The primary outcome was in\u2010hospital mortality and secondary outcomes were duration of hospitalization, duration of intensive care unit (\n ICU<\/jats:styled-content>\n ) stay, and requirement of mechanical ventilation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 135 patients with suspected CAP were included in the study. Of these, 59 patients were RT\u2010PCR positive for H1N1 virus, and 76 patients were RT\u2010PCR negative. Patients with H1N1 pneumonia were significantly younger than those with CAP of other origin (46.0\u00a0years vs. 68.0\u00a0years, p\u00a0<\u00a00.01) and more frequently had nonspecific symptoms (p\u00a0<\u00a00.01), initial leukopenia (8.5% vs. 0.0%, p\u00a0=\u00a00.01), lymphopenia (45.8% vs. 26.3%, p\u00a0=\u00a00.02), low values of C\u2010reactive protein (CRP; 5.2\u00a0mg\/\n dL<\/jats:styled-content>\n vs. 13.4\u00a0mg\/\n dL<\/jats:styled-content>\n , p\u00a0=\u00a00.02), bilateral abnormalities (57.7% vs. 29.7%, p\u00a0<\u00a00.01) on chest radiography, ground glass opacities (43.9% vs. 12.8%, p\u00a0<\u00a00.01) on chest computed tomography, and low values of pneumonia severity index (PSI) score (56.0 vs. 91.0, p\u00a0<\u00a00.01) than those with CAP of other origin. However, there were no significant differences in infection severity, clinical outcome, length of ICU stay, requirement for mechanical ventilation, and mortality between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study shows that clinical characteristics and outcomes of 2009 H1N1 pneumonia are comparable to those of\n CAP<\/jats:styled-content>\n of other origin. However, some characteristics, including younger age, nonspecific symptoms (including headache, leukopenia, and fatigue), lymphopenia, lower initial\n CRP<\/jats:styled-content>\n and\n PSI<\/jats:styled-content>\n score, and radiologic findings (including bilateral abnormalities and ground glass opacities), may help clinicians to diagnostically differentiate between H1N1 pneumonia and\n CAP<\/jats:styled-content>\n of other origin before the result of\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n are obtained.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acem.12062","type":"journal-article","created":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T20:30:31Z","timestamp":1358109031000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Clinical Features and Outcomes of Hospitalized Adult Patients With Novel Influenza A (H1N1) Pneumonia and Other Pneumonia"],"prefix":"10.1111","volume":"20","author":[{"given":"Chang Hwan","family":"Sohn","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Mok","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Bum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicines Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Man","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicines Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Suck","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicines Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"467","article-title":"Outbreak of swine\u2010origin influenza A (H1N1) virus infection \u2010 Mexico, March\u2010April 2009","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_3_1","first-page":"261","article-title":"New influenza A (H1N1) virus: WHO guidance on public health measures, 11 June 2009","volume":"84","author":"Anonymous","year":"2009","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.Pandemic (H1N1) 2009 \u2010 Update 98. 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