{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:51:29Z","timestamp":1791582689130,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Liposome (<jats:styled-content style=\"fixed-case\">LIP<\/jats:styled-content>)\u2010like lipid dispersions have emerged as useful detoxification vehicles in vitro. The authors compare resuscitation with tailored <jats:styled-content style=\"fixed-case\">LIP<\/jats:styled-content>s, 20% intravenous lipid emulsion (<jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content>), and sodium bicarbonate (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>), in a rabbit model of clomipramine toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sedated, instrumented New Zealand white rabbits underwent clomipramine infusion at 3.2\u00a0mg\/kg\/min to 50% baseline mean arterial pressure (MAP) and then at 1.6\u00a0mg\/kg\/min for 30\u00a0minutes. BIC (3\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/kg 8.4%), ILE (3\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/kg 20%), or LIP (24\u00a0mg\/kg) were infused as rescue treatments at toxicity and were repeated at 10\u00a0minutes (<jats:italic>n<\/jats:italic>\u00a0=\u00a05 in each group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010minute <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> was greatest in <jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content>\u2010treated animals: 61\u00a0mm\u00a0Hg <jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content> (interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>]\u00a0= 49 to 64\u00a0mm\u00a0Hg), 43\u00a0mm\u00a0Hg <jats:styled-content style=\"fixed-case\">LIP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a0= 36.5 to 49\u00a0mm\u00a0Hg), and 10\u00a0mm\u00a0Hg <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a0= 10 to 44\u00a0mm\u00a0Hg; all p\u00a0=\u00a00.02). Two of the five <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>\u2010treated animals survived to 30\u00a0minutes, compared with all five of the <jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content>\u2010treated animals and all five of the <jats:styled-content style=\"fixed-case\">LIP<\/jats:styled-content>\u2010treated animals (p\u00a0=\u00a00.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LIP<\/jats:styled-content>s improved hemodynamic recovery compared with bicarbonate in clomipramine\u2010induced cardiotoxicity in rabbits. Greater 30\u2010minute <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> was observed in the <jats:styled-content style=\"fixed-case\">ILE<\/jats:styled-content> group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12224","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T03:16:33Z","timestamp":1381893393000},"page":"1076-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of Intravenous Lipid Emulsion, Bicarbonate, and Tailored Liposomes in Rabbit Clomipramine Toxicity"],"prefix":"10.1111","volume":"20","author":[{"given":"Grant","family":"Cave","sequence":"first","affiliation":[{"name":"Tamworth Rural Referral Hospital Tamworth NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Damitz","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering University of Florida Gainesville 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