{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:24:58Z","timestamp":1768778698737,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Chest pain is a common complaint to emergency departments (ED<\/jats:styled-content>s) and clinical risk factors are used to predict which patients are at risk for worse outcomes and mortality. The goal was to assess the novel biomarker midregional proadrenomedullin (MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content>) in prediction of mortality and major adverse cardiac events (MACE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a subanalysis of the CHOPIN<\/jats:styled-content> study, a 16\u2010center prospective trial that enrolled 2,071 patients presenting with chest pain within 6\u00a0hours of onset. The primary endpoint was 6\u2010month all\u2010cause mortality and the secondary endpoint was 30\u2010day and 6\u2010month MACE<\/jats:styled-content>: ED<\/jats:styled-content> visits or hospitalization for acute myocardial infarction, unstable angina, reinfarction, revascularization, and heart failure.<\/jats:p><\/jats:sec>Results<\/jats:title>MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content> performed similarly to troponin (cTnI<\/jats:styled-content>; c\u2010statistic\u00a0=\u00a00.845 and 0.794, respectively) for mortality prediction in all subjects and had similar results in those with noncardiac diagnoses. MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content> concentrations were stratified by decile, and the cohort in the top decile had a 9.8% 6\u2010month mortality risk versus 0.9% risk for those in the bottom nine deciles (p\u00a0<\u00a00.0001). MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content>, history of coronary artery disease (CAD<\/jats:styled-content>), and hypertension were predictors of short\u2010term MACE<\/jats:styled-content>, while history of CAD<\/jats:styled-content>, hypertension, cTnI<\/jats:styled-content>, and MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content> were predictors of long\u2010term MACE.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In patients with chest pain, MR<\/jats:styled-content>\u2010proADM<\/jats:styled-content> predicts mortality and MACE<\/jats:styled-content> in all\u2010comers with chest pain and has similar prediction in those with a noncardiac diagnosis. This exploratory analysis is primarily hypotheses\u2010generating and future prospective studies to identify its utility in risk stratification should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12649","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T01:08:59Z","timestamp":1429837739000},"page":"554-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Midregional Proadrenomedullin Predicts Mortality and Major Adverse Cardiac Events in Patients Presenting With Chest Pain: Results From the CHOPIN<\/scp> Trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Kevin S.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Marston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean\u2010Xavier","family":"Neath","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Christenson","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Maryland Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"McCord","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Henry Ford Health System Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Henry Ford Health System Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Vilke","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori B.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judd E.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Thomas Jefferson University Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred S.","family":"Apple","sequence":"additional","affiliation":[{"name":"Department of Pathology Hennepin County Medical Center and University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Kansas Hospital Kansas City KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Nagurney","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Massachusetts General Hospital Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Stanford University School of Medicine Palo Alto CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"deFilippi","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Maryland Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Surgery Virginia Commonwealth University Richmond VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah B.","family":"Diercks","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California, Davis Medical Center Sacramento CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Limkakeng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Duke University Medical Center Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inder S.","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Cardiology Veterans Administration Hospital Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H. B.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Clopton","sequence":"additional","affiliation":[{"name":"Department of Research Veterans Affairs Medical Center San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Frank","family":"Peacock","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Maisel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of California San Diego CA"},{"name":"Department of Cardiology Veterans Affairs Medical Center San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Emergency department visits for chest pain and abdominal pain: United States, 1999\u20102008","volume":"43","author":"Bhuiya F","year":"2010","journal-title":"NCHS Data Brief"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary","volume":"7","author":"Pitts SR","year":"2008","journal-title":"Natl Health Stat Rep"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.The Top 10 Causes of Death. Available at:http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/. Accessed Feb 4 2015."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.835"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi187"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl133"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.19.2345"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38985.646481.55"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1860"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.031369"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03086144"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.255"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht218"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1080"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.07.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.4.R1392"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.6013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.12.1298"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.06.019"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"MorgenthalerNG StruckJ AlonsoC BergmannA.Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay.2005;51:1823\u20139.","DOI":"10.1373\/clinchem.2005.051110"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.01.064"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878708"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920467"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1827"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.2.138"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0279-5"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00513-7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.025"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.09.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2011.01150.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610313351802"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610313351801"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000403"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.110773"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.161166"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192278"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2013.874662"},{"key":"e_1_2_7_43_1","first-page":"w13542","article-title":"Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community\u2010acquired pneumonia","volume":"142","author":"Suberviola B","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1981"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-184"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq031"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.063842"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/2197-425X-1-3"}],"container-title":["Academic Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facem.12649","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acem.12649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T13:31:18Z","timestamp":1694439078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acem.12649"}},"subtitle":[],"editor":[{"given":"Brian","family":"Hiestand","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/acem.12649"],"URL":"https:\/\/doi.org\/10.1111\/acem.12649","archive":["Portico"],"relation":{},"ISSN":["1069-6563","1553-2712"],"issn-type":[{"value":"1069-6563","type":"print"},{"value":"1553-2712","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]},"assertion":[{"value":"2014-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}