{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:01:26Z","timestamp":1784088086128,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore","award":["1 UL1 TR001073-01"],"award-info":[{"award-number":["1 UL1 TR001073-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective was to test the hypothesis that oxycodone\/acetaminophen provides superior analgesia to hydrocodone\/acetaminophen for the treatment of acute extremity pain following emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, randomized, double\u2010blind clinical trial of nonelderly adult <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> patients with acute musculoskeletal extremity pain, randomly allocated at discharge to receive oxycodone\/acetaminophen (5 mg\/325 mg) or hydrocodone\/acetaminophen (5 mg\/325 mg). The primary outcome was the between\u2010group difference in improvement in numerical rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>) pain scores over a 2\u2010hour period following the most recent ingestion of study drug, obtained during telephone contact 24 hours after <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> discharge. Secondary outcomes included proportionate decrease in pain, comparative side\u2010effect profiles, and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 240 patients were enrolled. The final sample consisted of 220 patients, 107 randomly allocated to oxycodone\/acetaminophen and 113 to hydrocodone\/acetaminophen. At 24 hours after <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> discharge, the mean <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain scores prior to the most recent dose of outpatient pain medication were 7.8 and 7.9 in the oxycodone\/acetaminophen and hydrocodone\/acetaminophen groups, respectively. The mean decreases in pain scores over 2 hours were 4.4 <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> units in the oxycodone\/acetaminophen group versus 4.0 <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> units in the hydrocodone\/acetaminophen group, for a difference of 0.4 <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> units (95% confidence interval = \u22120.2 to 1.1 <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> units). Satisfaction with the analgesics was similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study design could not detect a clinically or statistically significant difference in analgesic efficacy between oxycodone\/acetaminophen (5 mg\/325 mg) and hydrocodone\/acetaminophen (5 mg\/325 mg) for treatment of acute musculoskeletal extremity pain in adults following <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> discharge. Both opioids reduced pain scores by approximately 50%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12813","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T18:36:50Z","timestamp":1445279810000},"page":"1254-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparative Analgesic Efficacy of Oxycodone\/Acetaminophen Versus Hydrocodone\/Acetaminophen for Short\u2010term Pain Management in Adults Following <scp>ED<\/scp> Discharge"],"prefix":"10.1111","volume":"22","author":[{"given":"Andrew K.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Albert Einstein College of Medicine Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly E.","family":"Bijur","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Albert Einstein College of Medicine Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Albert Einstein College of Medicine Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. John","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Albert Einstein College of Medicine Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"National Hospital Ambulatory Medical Care Survey: 2007 emergency department summary","author":"Niska R","year":"2010","journal-title":"Natl Health Stat Rep"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2004.12.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2003.tb01355.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2026.2003.00499.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70226-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.04.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12830"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12331"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1994.tb02800.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_12_1","unstructured":"National Center for Health Statistics.National Hospital Ambulatory Medical Care Survey: 2011 Emergency Department Summary Tables. Available at:http:\/\/www.cdc.gov\/nchs\/data\/ahcd\/nhamcs_emergency\/2011_ed_web_tables.pdf. Accessed Aug 31 2015."},{"key":"e_1_2_8_13_1","first-page":"49661","article-title":"Schedules of controlled substances: rescheduling of hydrocodone combination products from schedule III to schedule II. Final rule","volume":"79","author":"Department of Justice","year":"2014","journal-title":"Fed Regist"},{"key":"e_1_2_8_14_1","first-page":"40","article-title":"Guidelines for scheduling drugs under the controlled substances act [proceedings]","volume":"17","author":"Kartzinel R","year":"1981","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1139"}],"container-title":["Academic Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facem.12813","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acem.12813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:57:47Z","timestamp":1695560267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acem.12813"}},"subtitle":[],"editor":[{"given":"James","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/acem.12813"],"URL":"https:\/\/doi.org\/10.1111\/acem.12813","archive":["Portico"],"relation":{},"ISSN":["1069-6563","1553-2712"],"issn-type":[{"value":"1069-6563","type":"print"},{"value":"1553-2712","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]},"assertion":[{"value":"2015-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}