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Our objective was to compare patient satisfaction with three analgesia regimens prescribed for post\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> care\u2014a nasally administered nonsteroidal anti\u2010inflammatory drug (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>), an opioid, or combination therapy\u2014by collecting granular follow\u2010up on analgesic use, pain scores, side effects, work activity levels, and overall satisfaction directly from patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a prospective registry linking <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> assessment and analgesic management for acute pain of specific musculoskeletal or visceral etiologies with self\u2010reported automated telephonic follow\u2010up daily for the 4\u00a0days post\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> discharge. Patients were prescribed a specific <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SPRIX<\/jats:styled-content>, ketorolac tromethamine for nasal instillation) only, an oral opioid only, or both with the opioid clearly defined as rescue therapy, at the <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> provider's discretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 824 evaluable subjects. Maximum pain scores improved day to day more effectively with a ketorolac\u2010based approach. Self\u2010reported rates of return to work and work effectiveness were higher with <jats:styled-content style=\"fixed-case\">SPRIX<\/jats:styled-content> than with opioids or combination therapy. Adverse effects of nausea, constipation, drowsiness, and abdominal pain were higher each day among patients taking an opioid; nasal irritation was more common with <jats:styled-content style=\"fixed-case\">SPRIX<\/jats:styled-content>. Overall satisfaction at the end of the follow\u2010up period was higher with <jats:styled-content style=\"fixed-case\">SPRIX<\/jats:styled-content>\u2010based treatment than with opioid monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Automated telephonic follow\u2010up of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> patients prescribed short\u2010term analgesia is feasible. Ketorolac\u2010based analgesia after an <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> visit for many acute pain syndromes was associated with favorable patient outcomes and higher satisfaction than opioid\u2010based therapy. <jats:styled-content style=\"fixed-case\">SPRIX<\/jats:styled-content>, an <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> that is not available over the counter and has a novel delivery approach, may be useful for short\u2010term post\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> outpatient analgesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.12902","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T07:38:37Z","timestamp":1453189117000},"page":"331-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Patient\u2010reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management With an Intranasal Nonsteroidal Anti\u2010inflammatory Drug, Opioids, or Both"],"prefix":"10.1111","volume":"23","author":[{"suffix":"Jr.","given":"Charles V.","family":"Pollack","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Thomas Jefferson University Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah B.","family":"Diercks","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California Davis Medical Center Sacramento CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Oklahoma College of Medicine Tulsa OK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan I.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Beth Israel Deaconess Medical Center Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fanikos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Brigham and Women's Hospital Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon E.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubaid","family":"Rafique","sequence":"additional","affiliation":[{"name":"Section\u00a0of Emergency Medicine Department of Medicine Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knox H.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2007.64"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.401"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.03.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1833"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.01.017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.13.1710"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2010\/13\/401"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a95d86"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00003-6"},{"key":"e_1_2_7_11_1","first-page":"1487","article-title":"(CDC). 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