{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:58:36Z","timestamp":1780880316029,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23GM110469"],"award-info":[{"award-number":["K23GM110469"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K12HL109019"],"award-info":[{"award-number":["K12HL109019"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL125670"],"award-info":[{"award-number":["K23HL125670"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ultrasound\u2010guided intravenous catheter (<jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content>) insertion is increasingly being used for administration of intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) contrast for computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scans. The goal of this investigation was to evaluate the risk of contrast extravasation among patients receiving contrast through <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content> catheters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study of adult patients who underwent a contrast\u2010enhanced <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan at a tertiary care emergency department during a recent 64\u2010month period was conducted. The unadjusted prevalence of contrast extravasation was compared between patients with an <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content> and those with a standard peripheral <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> inserted without ultrasound. Then, a two\u2010stage sampling design was used to select a subset of the population for a multivariable logistic regression model evaluating <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content>s as a risk factor for extravasation while adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 40,143 patients underwent a contrasted <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan, including 364 (0.9%) who had contrast administered through an <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content>. Unadjusted prevalence of extravasation was 3.6% for contrast administration through <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content>s and 0.3% for standard <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>s (relative risk = 13.9, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] = 7.9 to 24.6). After potential confounders were adjusted for, <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> contrast administered through <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content>s was associated with extravasation (adjusted odds ratio = 8.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 4.6 to 16.2). No patients required surgical management for contrast extravasation; one patient in the standard <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> group was admitted for observation due to extravasation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who received contrast for a <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan through an <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content> had a higher risk of extravasation than those who received contrast through a standard peripheral <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Clinicians should consider this extravasation risk when weighing the risks and benefits of a contrast\u2010enhanced <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan in a patient with <jats:styled-content style=\"fixed-case\">USGIV<\/jats:styled-content> vascular access.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.13000","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T10:22:47Z","timestamp":1462530167000},"page":"918-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Extravasation Risk Using Ultrasound\u2010guided Peripheral Intravenous Catheters for Computed Tomography Contrast Administration"],"prefix":"10.1111","volume":"23","author":[{"given":"Jordan D.","family":"Rupp","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robinson M.","family":"Ferre","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dearing","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace D.","family":"McNaughton","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli L.","family":"Jarrell","sequence":"additional","affiliation":[{"name":"School of Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor M.","family":"McWade","sequence":"additional","affiliation":[{"name":"School of Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley H.","family":"Self","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2012-201652"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-013-1185-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970115)16:1<103::AID-SIM474>3.0.CO;2-P"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.02.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2011.07.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.08.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.04.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200406000-00013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.9.1159"}],"container-title":["Academic Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facem.13000","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acem.13000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:19:31Z","timestamp":1695755971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acem.13000"}},"subtitle":[],"editor":[{"given":"Timothy B.","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/acem.13000"],"URL":"https:\/\/doi.org\/10.1111\/acem.13000","archive":["Portico"],"relation":{},"ISSN":["1069-6563","1553-2712"],"issn-type":[{"value":"1069-6563","type":"print"},{"value":"1553-2712","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"2016-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}