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Clinical endpoints (diagnosis, treatment, complications, and mortality) and their corresponding cost data (2016 USD<\/jats:styled-content>) were obtained by performing a best evidence review of the published literature. Studies were pooled and parameters were weighted by sample size. Outcomes measured included differences in 1) excess costs, 2) total costs, and 3) lives lost per annum between SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> and the other imaging modalities. One\u2010way (\u00b125%) sensitivity and three scenario analyses were performed to gauge the robustness of the results.<\/jats:p><\/jats:sec>Results<\/jats:title>For every 1,000 suspected PE<\/jats:styled-content> patients undergoing imaging, expected annual economic burden by modality was found to be 3.2 million (SPECT<\/jats:styled-content>\/CT<\/jats:styled-content>), 3.8 million (CTPA<\/jats:styled-content>), 5.8 million (planar), and 3.6 million (SPECT<\/jats:styled-content>) USD<\/jats:styled-content>, with a switch to SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> technology yielding per\u2010patient\u2010per\u2010month cost savings of $51.80 (vs. CTPA<\/jats:styled-content>), $213.80 (vs. planar), and $36.30 (vs. SPECT<\/jats:styled-content>), respectively. The model calculated that the incremental number of lives saved with SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> was six (vs. CTPA<\/jats:styled-content>) and three (vs. planar). Utilizing SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> as the initial imaging modality for workup of acute PE<\/jats:styled-content> was also expected to save $994,777 (vs. CTPA<\/jats:styled-content>), $2,852,014 (vs. planar), and $435,038 (vs. SPECT<\/jats:styled-content>) in \u201cpotentially avoidable\u201d\u2019 excess costs per annum for a payer or health plan.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Compared to the currently available scanning technologies for diagnosing suspected PE<\/jats:styled-content>, SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> appears to confer superior economic value, primarily via improved sensitivity and specificity and low nondiagnostic rates. 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