{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:51:15Z","timestamp":1791607875337,"version":"4.3.4"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We aimed to clarify the definition, epidemiology, and pathophysiology of excited delirium syndrome (Ex\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      ) and to summarize evidence\u2010based treatment recommendations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic literature search of\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      , Ovid, Web of Knowledge, and Cochrane Library for articles published to March 18, 2017. We also searched the gray literature (Google Scholar) and official police or medical expert reports to complete specific epidemiologic data. Search results and full\u2010text articles were independently assessed by two investigators and agreements between reviewers assessed with K statistics. We classified articles by study type, setting, and evidence level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After reviewing the title and abstract of 3,604 references, we fully reviewed 284 potentially relevant references, from which 66 were selected for final review. Six contributed to the definition of Ex\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      , 24 to its epidemiology, 38 to its pathophysiology, and 27 to its management. The incidence of Ex\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      varies widely with medical or medicolegal context. Mortality is estimated to be as much as 8.3% to 16.5%. Patients are predominantly male. Male sex, young age, African\u2010American race, and being overweight are independent risk factors. Pathophysiology hypotheses mostly implicate dopaminergic pathways. Most cases occur with psychostimulant use or among psychiatric patients or both. Proposed treatments are symptomatic, often with rapid sedation with benzodiazepines or antipsychotic agents. Ketamine is suggested as an alternative.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The overall quality of studies was poor. A universally recognized definition is lacking, remaining mostly syndromic and based on clinical subjective criteria. High mortality rate may be due to definition inconsistency and reporting bias. Our results suggest that Ex\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      is a real clinical entity that still kills people and that has probably specific mechanisms and risk factors. No comparative study has been performed to conclude whether one treatment approach is preferable to another in the case of Ex\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.13330","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T04:34:37Z","timestamp":1507523677000},"page":"552-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Excited Delirium: A Systematic Review"],"prefix":"10.1111","volume":"25","author":[{"given":"Philippe","family":"Gonin","sequence":"first","affiliation":[{"name":"Emergency Department Lausanne University Hospital CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Beysard","sequence":"additional","affiliation":[{"name":"Emergency Department Lausanne University Hospital CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Yersin","sequence":"additional","affiliation":[{"name":"Emergency Department Lausanne University Hospital CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Nicolas","family":"Carron","sequence":"additional","affiliation":[{"name":"Emergency Department Lausanne University Hospital CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2009.01182.x"},{"key":"e_1_2_9_3_1","first-page":"525","article-title":"Are times getting tougher? 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