{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:30:54Z","timestamp":1780543854020,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of our study was to determine whether prehospital double sequential defibrillation (<jats:styled-content style=\"fixed-case\">DSD<\/jats:styled-content>) is associated with improved survival to hospital admission in the setting of refractory ventricular fibrillation\/pulseless ventricular tachycardia (<jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">pVT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This project is a matched case\u2013control study derived from prospectively collected quality assurance\/quality improvement data obtained from the San Antonio Fire Department out\u2010of\u2010hospital cardiac arrest (<jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content>) database between January 2013 and December 2015. The cases were defined as <jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content> patients with refractory <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">pVT<\/jats:styled-content> who survived to hospital admission. The control group was defined as <jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content> patients with refractory <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">pVT<\/jats:styled-content> who did not survive to hospital admission. The primary variable in our study was prehospital <jats:styled-content style=\"fixed-case\">DSD<\/jats:styled-content>. The primary outcome of our study was survival to hospital admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3,469 consecutive <jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content> patients during the study period, 205 <jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content> patients met the inclusion criterion of refractory <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">pVT<\/jats:styled-content>. Using a predefined algorithm, two blinded researchers identified 64 unique cases and matched them with 64 unique controls. Survival to hospital admission occurred in 48.0% of <jats:styled-content style=\"fixed-case\">DSD<\/jats:styled-content> patients and 50.5% of the conventional therapy patients (p\u00a0&gt;\u00a00.99; odds ratio\u00a0= 0.91, 95% confidence interval\u00a0= 0.40\u20132.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our matched case\u2013control study on the prehospital use of <jats:styled-content style=\"fixed-case\">DSD<\/jats:styled-content> for refractory <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">pVT<\/jats:styled-content> found no evidence of associated improvement in survival to hospital admission. Our current protocol of considering prehospital <jats:styled-content style=\"fixed-case\">DSD<\/jats:styled-content> after the third conventional defibrillation in <jats:styled-content style=\"fixed-case\">OHCA<\/jats:styled-content> is ineffective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.13672","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T06:16:32Z","timestamp":1544508992000},"page":"994-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prehospital Double Sequential Defibrillation: A Matched Case\u2013Control Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-9189","authenticated-orcid":false,"given":"Julian G.","family":"Mapp","sequence":"first","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium JBSA Fort Sam Houston TX"},{"name":"Department of Emergency Health Sciences University of Texas Health Science Center at San Antonio San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Hans","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium JBSA Fort Sam Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Darrington","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium JBSA Fort Sam Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot M.","family":"Ross","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium JBSA Fort Sam Houston TX"},{"name":"Department of Emergency Health Sciences University of Texas Health Science Center at San Antonio San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin 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