{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:32:08Z","timestamp":1783542728446,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24AT009893"],"award-info":[{"award-number":["K24AT009893"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nitrous oxide (N O) is an inhalational medication that has anxiolytic, amnestic, potent venodilatory and mild\u2010to\u2010moderate analgesic properties commonly used in the emergency department (ED) setting. N<jats:sub>2<\/jats:sub>O has a rapid onset of action (&lt;5 minutes) and recovery (&lt;5 minutes) and can be quickly titrated to effect without the need for IV access. It has few side effects, does not require renal or hepatic metabolism for excretion and has no reports of allergic reaction. Priapism is a serious complication of sickle cell disease (SCD) affecting approximately 35% of males, with an adverse impact on quality of life. Treatment options are limited and not evidence based, including hydration, alkalization, analgesia, oxygenation to prevent further sickling, and exchange transfusion. Patients who do not respond within 4 hours often require a painful invasive procedure that includes aspiration of blood from the corpus cavernosum and phenylephrine injections. Case reports have described a therapeutic benefit from oral pseudoephedrine, sildenafil, and intravenous (IV) arginine, however controlled clinical trials are lacking. Although a 50:50 nitrous oxide\/oxygen mix is commonly used in France to enhance analgesia in patients with SCD and vasoocclusive pain events (VOE) not sufficiently responding to IV morphine, there are no reports of its use to treat priapism. We describe the effects of N<jats:sub>2<\/jats:sub>O for the treatment of acute priapism associated with SCD in a pediatric ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case series of two adolescent boys with Hb\u2010SS who on 3 separate occasions presented to the ED with acute priapism that failed oral therapy (pseudoephedrine and opioids). N<jats:sub>2<\/jats:sub>O gas was utilized to help facilitate IV catheter placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In each presentation (at ages 8 and 10 years for patient 1; age 15 years for patient 2), the patient experienced complete resolution of the priapism within 4\u201015 min of receiving N<jats:sub>2<\/jats:sub>O (max 60%). The patients were discharged from the ED following each presentation and had no recurrence during the subsequent week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Priapism is a challenging complication of SCD associated with long\u2010term morbidity and a paucity of treatment options. Opioids are commonly used. Given the risks and inconsistent results of current recommended therapy, N<jats:sub>2<\/jats:sub>O may represent a potential opioid\u2010sparing treatment option for priapism presenting to the ED that warrants further investigation. Although anecdotal, N<jats:sub>2<\/jats:sub>O inhalation is an intervention to consider during a time when a treating ED physician may have few alternatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.13822","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T23:03:11Z","timestamp":1561244591000},"page":"1102-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resolution of Acute Priapism in Two Children With Sickle Cell Disease Who Received Nitrous Oxide"],"prefix":"10.1111","volume":"26","author":[{"given":"Michael H.","family":"Greenwald","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Emergency Medicine Emory University School of Medicine Atlanta GA"},{"name":"Children's Healthcare of Atlanta Atlanta 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