{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:33:27Z","timestamp":1793997207413,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002076","name":"Emergency Medicine Foundation","doi-asserted-by":"publisher","award":["EMTR\u2010101R23\u20102015"],"award-info":[{"award-number":["EMTR\u2010101R23\u20102015"]}],"id":[{"id":"10.13039\/100002076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001238","name":"Society of Hospital Pharmacists of Australia","doi-asserted-by":"publisher","award":["SHPA Emergency Medicine Grant 2014 (EME 1402)"],"award-info":[{"award-number":["SHPA Emergency Medicine Grant 2014 (EME 1402)"]}],"id":[{"id":"10.13039\/501100001238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to describe the incidence, nature, and risk factors for adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s) among patients who received parenteral sedation for acute agitation in an emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a prospective observational study and a clinical trial of parenteral sedation for the management of acute agitation. We included agitated adult patients who required parenteral sedation from 2014 to 2017 in 12 Australian <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>s, excluding those with incomplete information or aged under 18 years. The primary outcome was the number of patients who experienced at least one <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. Multivariable logistic regression was used to determine factors associated with <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 904 patients were included in the analyses (62.3% male; median age\u00a0= 34 years, range\u00a0= 18 to 95 years). Of these, 144 (15.9%) patients experienced at least one <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. The most common <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s were oxygen desaturation (7.4%), airway obstruction (3.6%), bradycardia (1.9%), hypotension (1.7%), and prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval (1.3%). No deaths or serious <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s were reported. The following factors had an increased adjusted odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) for experiencing an <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>: age 65 years and older (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0= 2.8, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]\u00a0= 1.2 to 7.2), more than one type of parenteral sedation administered within 60 minutes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0= 2.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0= 1.4 to 3.1), and alcohol intoxication (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0= 1.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0= 1.2 to 2.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sedation\u2010related <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s are common, especially respiratory events. Elderly patients, sedation with multiple sedatives within 60 minutes, and alcohol intoxication increased the risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.13826","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T16:38:28Z","timestamp":1562085508000},"page":"1135-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk Factors for Sedation\u2010related Events During Acute Agitation Management in the Emergency Department"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8359-0605","authenticated-orcid":false,"given":"Celene Y. L.","family":"Yap","sequence":"first","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Parkville Victoria"},{"name":"Centre for Integrated Critical Care Department of Medicine and Radiology Melbourne Medical School The University of Melbourne Parkville Victoria"},{"name":"Emergency Department The Royal Melbourne Hospital Parkville Victoria"},{"name":"Centre for Medicine Use and Safety Monash University Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-9997","authenticated-orcid":false,"given":"David McD.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Parkville Victoria"},{"name":"Centre for Integrated Critical Care Department of Medicine and Radiology Melbourne Medical School The University of Melbourne Parkville Victoria"},{"name":"Emergency Department Austin Health Heidelberg Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C. M.","family":"Kong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Parkville Victoria"},{"name":"Centre for Medicine Use and Safety Monash University Parkville Victoria"},{"name":"Pharmacy Department Ballarat Health Services Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-0440","authenticated-orcid":false,"given":"Jonathan C.","family":"Knott","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Parkville Victoria"},{"name":"Centre for Integrated Critical Care Department of Medicine and Radiology Melbourne Medical School The University of Melbourne Parkville Victoria"},{"name":"Emergency Department The Royal Melbourne Hospital Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Pharmacy Department Austin Health Heidelberg Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Sedation for Acute Agitation in Emergency Department Patients: Targeting Adverse Events (SIESTA) Collaborative Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2018.06.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13173"},{"issue":"318","key":"e_1_2_8_4_1","first-page":"e1","article-title":"Midazolam\u2010droperidol, droperidol, or olanzapine for acute agitation: a randomized clinical trial","volume":"69","author":"Taylor DM","year":"2017","journal-title":"Ann Emerg Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2005.07.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.05.037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2012.07.118"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2005.07.017"},{"key":"e_1_2_8_9_1","article-title":"Management of behavioural emergencies: a prospective observational study in Australian emergency departments","author":"Yap CY","year":"2019","journal-title":"JPPR"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02799-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565090-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2017.11.031"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2013.00026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-199709000-00003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13780"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)82660-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990500120736"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n1004"},{"key":"e_1_2_8_19_1","first-page":"CD002830","article-title":"Droperidol for acute psychosis","author":"Cure S","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.03.026"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3181d6d9f2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(03)00044-1"},{"key":"e_1_2_8_23_1","first-page":"3","article-title":"Rinetti D, Derlet RW. 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