{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:43:58Z","timestamp":1787798638491,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with cannabinoid hyperemesis syndrome (CHS) present frequently to the emergency department. Previous case studies suggest dramatic symptomatic improvement with topical capsaicin treatment. This exploratory study examined the potential effectiveness of topical capsaicin in patients with nausea and vomiting due to a suspected CHS exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a double\u2010blind, randomized placebo\u2010controlled pilot trial. Adults who presented with vomiting suspected to be from CHS were eligible for enrollment. We excluded pregnant women and those with resolution of symptoms. Following randomization, topical 0.1% capsaicin or placebo cream was applied to the anterior abdomen in a uniform manner. The primary outcome was the severity of nausea on a visual analog scale (VAS) of 0 to 10\u00a0cm assessed at 30\u00a0minutes. Secondary outcomes were adverse events, occurrence of posttreatment vomiting, nausea by VAS at 60\u00a0minutes, and hospital admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This pilot trial enrolled 30 patients, 17 in the capsaicin arm and 13 in the placebo arm. One patient in the capsaicin arm did not tolerate treatment due to skin irritation. Mean\u00a0\u00b1 SD nausea severity at 30\u00a0minutes was 4.1\u00a0\u00b1\u00a02.3\u00a0cm in the capsaicin arm and 6.1\u00a0\u00b1\u00a03.3\u00a0cm in the placebo arm (difference\u00a0=\u00a0\u22122.0\u00a0cm, 95% confidence interval [CI]\u00a0=\u00a00.2 to \u22124.2\u00a0cm). At 60\u00a0minutes, mean\u00a0\u00b1 SD nausea severity was 3.2\u00a0\u00b1\u00a03.2\u00a0cm versus 6.4\u00a0\u00b1\u00a02.8\u00a0cm (difference\u00a0=\u00a0\u22123.2\u00a0cm, 95% CI\u00a0=\u00a0\u22120.9 to \u22125.4\u00a0cm). The percent reduction in nausea at 60\u00a0minutes from baseline was 46.0% in the capsaicin arm and 24.9% in the placebo arm (difference\u00a0=\u00a021.1%, 95% CI\u00a0=\u00a0\u22125.6% to 47.9%). A higher proportion of capsaicin group patients (29.4% vs. 0%) had complete resolution of nausea (relative risk\u00a0=\u00a03.4, 95% CI\u00a0=\u00a01.6 to 7.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot trial, the application of topical capsaicin cream was associated with a significant reduction in nausea at 60\u00a0minutes but not at 30\u00a0minutes and provided more complete relief of nausea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.14062","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T14:36:20Z","timestamp":1592836580000},"page":"1166-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Pilot Trial of Topical Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-8005","authenticated-orcid":false,"given":"Diana J.","family":"Dean","sequence":"first","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"},{"name":"the Michigan Poison Center Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Sabagha","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Rose","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"},{"name":"the Central Michigan University College of Medicine Mount Pleasant MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Weiss","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"France","sequence":"additional","affiliation":[{"name":"the Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Asmar","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Ann","family":"Rammal","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Beyer","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Bussa","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ross","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleem","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Smoot","sequence":"additional","affiliation":[{"name":"and the Frederick Memorial Hospital Frederick MD 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