{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:41:23Z","timestamp":1790840483031,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been reports of procoagulant activity in patients with COVID\u201019. Whether there is an association between pulmonary embolism (PE) and COVID\u201019 in the emergency department (ED) is unknown. The aim of this study was to assess whether COVID\u201019 is associated with PE in ED patients who underwent a computed tomographic pulmonary angiogram (CTPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study in 26 EDs from six countries. ED patients in whom a CTPA was performed for suspected PE during a 2\u2010month period covering the pandemic peak. The primary endpoint was the occurrence of a PE on CTPA. COVID\u201019 was diagnosed in the ED either on CT or reverse transcriptase\u2013polymerase chain reaction. A multivariable binary logistic regression was built to adjust with other variables known to be associated with PE. A sensitivity analysis was performed in patients included during the pandemic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,358 patients were included, of whom 105 were excluded because COVID\u201019 status was unknown, leaving 3,253 for analysis. Among them, 974 (30%) were diagnosed with COVID\u201019. Mean (\u00b1SD) age was 61 (\u00b119)\u00a0years and 52% were women. A PE was diagnosed on CTPA in 500 patients (15%). The risk of PE was similar between COVID\u201019 patients and others (15% in both groups). In the multivariable binary logistic regression model, COVID\u201019 was not associated with higher risk of PE (adjusted odds ratio\u00a0= 0.98, 95% confidence interval\u00a0= 0.76 to 1.26). There was no association when limited to patients in the pandemic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In ED patients who underwent CTPA for suspected PE, COVID\u201019 was not associated with an increased probability of PE diagnosis. These results were also valid when limited to the pandemic period. However, these results may not apply to patients with suspected COVID\u201019 in general.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.14096","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:54:13Z","timestamp":1596174853000},"page":"811-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Association Between Pulmonary Embolism and COVID\u201019 in Emergency Department Patients Undergoing Computed Tomography Pulmonary Angiogram: The PEPCOV International Retrospective Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-3848","authenticated-orcid":false,"given":"Yonathan","family":"Freund","sequence":"first","affiliation":[{"name":"From Sorbonne Universit\u00e9 Paris France"},{"name":"the Emergency Department H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), APHP.SU Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Drogrey","sequence":"additional","affiliation":[{"name":"the Emergency Department H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), APHP.SU Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"the Emergency Departement Hospital Cl\u00ednic Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Marra","sequence":"additional","affiliation":[{"name":"the Emergency Department Centro EAS\u2013Emergenza Alta Specializzazione ASST Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Laure","family":"F\u00e9ral\u2010Pierssens","sequence":"additional","affiliation":[{"name":"the Charles Lemoyne\u2013Saguenay Lac Saint\u2010Jean Research Center on Health Innovations (CR CSIS) Sherbrooke University Longueuil Qu\u00e9bec Canada"},{"name":"the Emergency Department European Georges Pompidou hospital APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Penaloza","sequence":"additional","affiliation":[{"name":"the Service des Urgences Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A. Lara","family":"Hernandez","sequence":"additional","affiliation":[{"name":"the Emergency Medicine Section Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Beaune","sequence":"additional","affiliation":[{"name":"the Emergency Department H\u00f4pital Ambroise\u2010Par\u00e9, APHP, Boulogne, INSERM UMR 1144 Universit\u00e9 Paris Centre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Gorlicki","sequence":"additional","affiliation":[{"name":"the Emergency Department SAMU 93 Avicenne University Hospital, APHP.HUPSSD Bobigny France"},{"name":"INSERM UMR\u2010S 942 Sorbonne Paris Nord University Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabakar","family":"Vaittinada Ayar","sequence":"additional","affiliation":[{"name":"the Emergency Department University Hospital of Beaujon, APHP Clichy 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