{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:02:55Z","timestamp":1773280975496,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>SARS\u2010CoV\u20102 is a global pandemic associated with significant morbidity and mortality. However, information from United States cohorts is limited. Understanding predictors of admission and critical illness in these patients is essential to guide prevention and risk stratification strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, registry\u2010based cohort study including all patients presenting to Rush University Medical Center in Chicago, Illinois, with COVID\u201019 from March 4, 2020 to June 21, 2020. Demographic, clinical, laboratory, and treatment data were obtained from the registry and compared between hospitalized and nonhospitalized patients as well as those with critical illness. We used logistic regression modeling to explore risk factors associated with hospitalization and critical illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8,673 COVID\u201019 patients were included in the study, of whom 1,483 (17.1%) were admitted to the hospital and 528 (6.1%) were admitted to the intensive care unit. Risk factors for hospital admission included advanced age, male sex (odds ratio [OR]\u00a0= 1.69, 95% confidence interval [CI]\u00a0= 1.44 to 1.98), Hispanic\/Latino ethnicity (OR\u00a0= 1.52, 95% CI\u00a0= 1.18 to 1.92), hypertension (OR\u00a0= 1.77, 95% CI\u00a0= 1.46 to 2.16), diabetes mellitus (OR\u00a0= 1.84, 95% CI\u00a0= 1.53 to 2.22), prior CVA (OR\u00a0= 3.20, 95% CI\u00a0= 1.99 to 5.14), coronary artery disease (OR\u00a0= 1.45, 95% CI\u00a0= 1.03 to 2.06), heart failure (OR\u00a0= 1.79, 95% CI\u00a0= 1.23 to 2.61), chronic kidney disease (OR\u00a0= 2.60, 95% CI\u00a0= 1.77 to 3.83), end\u2010stage renal disease (OR\u00a0= 2.22, 95% CI\u00a0= 1.12 to 4.41), cirrhosis (OR\u00a0= 2.03, 95% CI\u00a0= 1.42 to 2.91), fever (OR\u00a0= 1.43, 95% CI\u00a0= 1.19 to 1.71), and dyspnea (OR\u00a0= 4.53, 95% CI\u00a0= 3.75 to 5.47). Factors associated with critical illness included male sex (OR\u00a0= 1.45, 95% CI\u00a0= 1.12 to 1.88), congestive heart failure (OR\u00a0= 1.45, 95% CI\u00a0= 1.00 to 2.12), obstructive sleep apnea (OR\u00a0= 1.58, 95% CI\u00a0= 1.07 to 2.33), blood\u2010borne cancer (OR\u00a0= 3.53, 95% CI\u00a0= 1.26 to 9.86), leukocytosis (OR\u00a0= 1.53, 95% CI\u00a0= 1.15 to 2.17), elevated neutrophil\u2010to\u2010lymphocyte ratio (OR\u00a0= 1.61, 95% CI\u00a0= 1.20 to 2.17), hypoalbuminemia (OR\u00a0= 1.80, 95% CI\u00a0= 1.39 to 2.32), elevated AST (OR\u00a0= 1.66, 95% CI\u00a0= 1.20 to 2.29), elevated lactate (OR\u00a0= 1.95, 95% CI\u00a0= 1.40 to 2.73), elevated D\u2010Dimer (OR\u00a0= 1.44, 95% CI\u00a0= 1.05 to 1.97), and elevated troponin (OR\u00a0= 3.65, 95% CI\u00a0= 2.03 to 6.57).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are a number of factors associated with hospitalization and critical illness. Clinicians should consider these factors when evaluating patients with COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.14104","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T01:45:36Z","timestamp":1596764736000},"page":"963-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Clinical Course and Factors Associated With Hospitalization and Critical Illness Among COVID\u201019 Patients in Chicago, Illinois"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-8375","authenticated-orcid":false,"given":"Michael","family":"Gottlieb","sequence":"first","affiliation":[{"name":"From the Department of Emergency Medicine Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Sansom","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine Division of Infectious Diseases Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Frankenberger","sequence":"additional","affiliation":[{"name":"and the Department of Cell and Molecular Medicine Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Ward","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bala","family":"Hota","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine Division of Infectious Diseases Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Situation Report 172. 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