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We aimed to determine the rate of ciTBI for each PECARN algorithm risk group in an external cohort of patients and that of ciTBI associated with different combinations of high\u2010 or intermediate\u2010risk predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a secondary analysis of a large multicenter prospective data set, including patients with Glasgow Coma Scale scores of 14 or 15 conducted in Australia and New Zealand. We calculated ciTBI rates with 95% confidence intervals (CIs) for each PECARN risk category and combinations of related predictor variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 15,163 included children, 4,011 (25.5%) were aged &lt;2\u00a0years. The frequency of ciTBI was 8.5% (95% CI\u00a0=\u00a06.0%\u201311.6%), 0.2% (95% CI\u00a0=\u00a00.0%\u20130.6%), and 0.0% (95% CI\u00a0=\u00a00.0%\u20130.2%) in the high\u2010, intermediate\u2010, and very\u2010low\u2010risk groups, respectively, for children &lt;2\u00a0years and 5.7% (95% CI\u00a0=\u00a04.4%\u20137.2%), 0.7% (95% CI\u00a0=\u00a00.5%\u20131.0%), and 0.0% (95% CI\u00a0=\u00a00.0%\u20130.1%) in older children. The isolated high\u2010risk predictor with the highest risk of ciTBI was \u201csigns of palpable skull fracture\u201d for younger children (11.4%, 95% CI\u00a0=\u00a05.3%\u201320.5%) and \u201csigns of basilar skull fracture\u201d in children \u22652\u00a0years (11.1%, 95% CI\u00a0=\u00a03.7%\u201324.1%). For older children in the intermediate\u2010risk category, the presence of all four predictors had the highest risk of ciTBI (25.0%, 95% CI\u00a0=\u00a00.6%\u201380.6%) followed by the combination of \u201csevere mechanism of injury\u201d and \u201csevere headache\u201d (7.7%, 95% CI\u00a0=\u00a00.2%\u201336.0%). The very few children &lt;2\u00a0years at intermediate risk with ciTBI precluded further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk estimates of ciTBI for each of the PECARN algorithms risk group were consistent with the original PECARN study. The risk estimates of ciTBI within the high\u2010 and intermediate\u2010risk predictors will help further refine clinical judgment and decision making on neuroimaging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.14308","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T11:16:17Z","timestamp":1625742977000},"page":"1124-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["PECARN algorithms for minor head trauma: Risk stratification estimates from a prospective PREDICT cohort study"],"prefix":"10.1111","volume":"28","author":[{"given":"Silvia","family":"Bressan","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health University of Padova Padova Italy"},{"name":"Clinical Sciences Murdoch Children's Research Institute Melbourne Victoria 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