{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:02:23Z","timestamp":1787162543815,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective was to systematically evaluate the sensitivity of diffusion\u2010weighted magnetic resonance imaging (DW\u2010MRI) for transient global amnesia (TGA) across various time frames compared to the reference\u2010standard clinical criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All indexed publications related to TGA and MRI through June 2020 were retrieved by a medical librarian. Two independent reviewers identified original research studies of adults with a clinical diagnosis of TGA using Caplan and Hodges and Warlow criteria (reference standard) who were evaluated with DW\u2010MRI. Pooled estimates and its 95% confidence intervals (CI) for the proportion of acute TGA patients with positive DW\u2010MRI (i.e., sensitivity) were obtained using random\u2010effects meta\u2010analysis for various time frames. Quality assessment was performed using the revised Quality of Assessment of Diagnostic Accuracy Studies (QUADAS\u20102) tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After screening 665 reports, we identified 81 potentially relevant studies. Twenty\u2010three studies representing 1688 patients met eligibility criteria, but not all studies had data available for meta\u2010analysis. The pooled sensitivity (also described as positivity rate) of DW\u2010MRI was 15.6% (95% CI\u00a0=\u00a02.6%\u201335.0%) between 0 and 12\u00a0h from symptom onset, 23.1% (95% CI\u00a0=\u00a06.1%\u201345.7%) at 0\u201324\u00a0h, 72.8% (95% CI\u00a0=\u00a040.8%\u201396.3) at 12\u201324\u00a0h, 68.8% (95% CI\u00a0=\u00a044.8%\u201388.8%) at 24\u201336\u00a0h, 72.4% (95% CI\u00a0=\u00a059.8%\u201383.5%) at 36\u201348\u00a0h, 82.8% (95% CI\u00a0=\u00a054.7%\u201399.6%) at 48\u201360\u00a0h, 66.9% (95% CI\u00a0=\u00a047.5%\u201383.9%) at 60\u201372\u00a0h, and 72.0% (95% CI\u00a0=\u00a030.1%\u2013100.0%) at 72\u201396\u00a0h. There was significant concern for risk of bias in the QUADAS\u20102 domains of patient selection and index test, yielding a low level of certainty in the pooled estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DW\u2010MRI lesions are uncommon in patients with TGA early after symptom onset, but the sensitivity (i.e., positivity rate) of DW\u2010MRI increases with time. Despite the limited quality of existing evidence, obtaining an early DW\u2010MRI in patients with clinical diagnosis of TGA in the acute setting is likely a low\u2010yield test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.14390","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T12:34:56Z","timestamp":1631536496000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sensitivity of diffusion\u2010weighted magnetic resonance imaging in transient global amnesia as a function of time from symptom onset"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-1421","authenticated-orcid":false,"given":"Matthew L.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts 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