{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:56Z","timestamp":1787013776262,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Reported risk of bleeding complications after central catheter access in patients with thrombocytopenia is highly variable. Current guidelines recommend routine prophylactic platelet (PLT) transfusion before central venous catheter placement in patients with severe thrombocytopenia. Nevertheless, the strength of such recommendations is weak and supported by observational studies including few patients with very low PLT counts (&lt;20\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L). This study aims to assess the risk of bleeding complications related to using or not using prophylactic PLT transfusion before ultrasound\u2010guided central venous access in patients with very low PLT counts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study of patients with very low PLT counts (&lt;20\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) subjected to ultrasound\u2010guided central venous catheterization between January 2011 and November 2019 in a university hospital. Bleeding complications were graded according to the Common Terminology Criteria for Adverse Events. A multivariate logistic regression was conducted to assess the risk of major and minor bleeding complications comparing patients who did or did not receive prophylactic PLT transfusion for the procedure. Multiple imputation by chained equations was used to handle missing data. A two\u2010tailed\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 221 patients with very low PLT counts, 72 received prophylactic PLT transfusions while 149 did not. Baseline characteristics were similar between transfused and nontransfused patients. No major bleeding events were identified, while minor bleeding events were recognized in 35.7% of patients. Multivariate logistic regression analysis showed no significant differences in bleeding complications between patients who received prophylactic PLT transfusions and those who did not (odds ratio 0.83, 95% confidence interval 0.45\u20131.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.567). Additional complete case and sensitivity analyses yielded results similar to those of the main analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective cohort study of ultrasound\u2010guided central venous access in patients with very low PLT counts, no major bleeding was identified, and prophylactic PLT transfusions did not significantly decrease minor bleeding events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.14651","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T09:58:33Z","timestamp":1672567113000},"page":"644-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prophylactic platelet transfusion and risk of bleeding associated with ultrasound\u2010guided central venous access in patients with severe thrombocytopenia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-1162","authenticated-orcid":false,"given":"Virginia","family":"Zarama","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Fundaci\u00f3n Valle del Lili  Cali Colombia"},{"name":"Facultad de Ciencias de la Salud Universidad Icesi  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Revelo\u2010Noguera","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Icesi  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-1761","authenticated-orcid":false,"given":"Jaime A.","family":"Quintero","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas (CIC) Fundaci\u00f3n Valle del Lili  Cali 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