{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:12:03Z","timestamp":1780477923348,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA055023"],"award-info":[{"award-number":["R21DA055023"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cannabinoid hyperemesis syndrome (CHS) is a clinical condition of cyclic vomiting, nausea, and abdominal pain associated with chronic cannabis use. Despite increased recognition of CHS, there are limited details on cannabis use practices and symptoms over time. Understanding what happens in the period surrounding the emergency department (ED) visit, including any changes in symptoms and cannabis use practices following the visit, can help inform the development of patient\u2010centered interventions around cannabis use disorder for patients with CHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational cohort (<jats:italic>n<\/jats:italic>\u2009=\u200939) of patients with suspected CHS recruited from the ED at the time of a symptomatic cyclic vomiting episode was followed for 3\u2009months. Disease progression, cannabis use practices, and health care utilization were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants reported high rates of persistent CHS symptoms (abdominal pain, nausea, or cyclic vomiting) in the 2\u2010week period immediately following an ED visit with a median duration of 7\u2009days. Cannabis use frequency and quantity were reduced immediately after the ED visit, but most participants returned to pre\u2010ED visit cannabis use patterns within a few days. Recurrent ED visits for cyclic vomiting were reported by 25% of participants who completed follow\u2010up during the 3\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Participants continued to have ongoing symptoms after the ED visit, but most managed symptoms on their own and did not return to the ED. Longitudinal studies beyond 3\u2009months are needed to better understand the clinical course of patients with suspected CHS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.14773","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T12:18:13Z","timestamp":1688127493000},"page":"463-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cannabinoid hyperemesis syndrome: Clinical trajectories and patterns of use three months following a visit to the emergency department"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-1776","authenticated-orcid":false,"given":"Rachel S.","family":"Wightman","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Metrik","sequence":"additional","affiliation":[{"name":"Center for Alcohol and Addiction Studies School of Public Health, Brown University  Providence Rhode Island USA"},{"name":"Providence VA Medical Center  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timmy R.","family":"Lin","sequence":"additional","affiliation":[{"name":"Brown Emergency Medicine  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra B.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca L.","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NIH.Marijuana and hallucinogen use among young adults reached all\u2010time high in 2021. 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