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Correct diagnosis of vertigo etiology is essential for early optimum treatment and disposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this systematic review and meta\u2010analysis was to summarize the published evidence on the potential of blood biomarkers in the diagnosis and differentiation of peripheral from central causes of AVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted for studies published until January 1, 2023, in PubMed, Ovid Medline, and EMBASE databases analyzing biomarkers for the differentiation between central and peripheral AVS. The Quality Assessment of Diagnostic Accuracy Studies questionnaire 2 was used for quality assessment. Pooled standardized mean difference and 95% confidence intervals were calculated if a biomarker was reported in two or more studies. Heterogeneity among included studies was investigated using the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> metric.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 studies with 859 central and 4844 peripheral causes of acute dizziness or vertigo, and analysis of 61 biomarkers were included. The general laboratory markers creatinine, blood urea nitrogen, albumin, C\u2010reactive protein, glucose, HbA1c, leukocyte counts, and neutrophil counts and the brain\u2010derived biomarkers copeptin, S100 calcium\u2010binding protein \u03b2 (S100\u03b2), and neuron\u2010specific enolase (NSE) significantly differentiated central from peripheral causes of AVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review and meta\u2010analysis highlights the potential of generalized inflammatory markers and brain\u2010specific blood protein markers of NSE and S100\u03b2 as diagnostic biomarkers for central from peripheral differentiation in AVS. These results, as a complement to clinical characteristics, provide guidance for future large\u2010scale diagnostic research, in this challenging ED patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.14864","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T05:29:05Z","timestamp":1708925345000},"page":"371-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood biomarkers for the differentiation between central and peripheral vertigo in the emergency department: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-1230","authenticated-orcid":false,"given":"Vincent W.","family":"Klokman","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Jeroen Bosch Hospital  's\u2010Hertogenbosch The Netherlands"},{"name":"Department of Vascular Surgery University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona N.","family":"Koningstein","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Jeroen Bosch Hospital  's\u2010Hertogenbosch The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Job W. 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