{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:15:46Z","timestamp":1791335746924,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","award":["75A50123C00041"],"award-info":[{"award-number":["75A50123C00041"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Determining etiology for adults with symptoms of lower respiratory tract infection (LRTI) is challenging. MeMed BV (MMBV), an FDA\u2010cleared blood test, computationally integrates the levels of three host proteins to differentiate bacterial and viral infections. We evaluated MMBV's impact on safe antibiotic prescribing at emergency department\/urgent care centers (ED\/UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The JUNO randomized controlled trial (RCT; NCT05762302) was a prespecified pilot phase of the JUPITER RCT. JUNO enrolled adult ED\/UC patients with LRTI symptoms and clinician's consideration for antibiotic treatment. Inclusion criteria were fever within 7\u2009days and one of cough, sputum production, dyspnea, or auscultation abnormality. Exclusion criteria were prior antibiotic use or immunosuppression. Patients were randomized to standard care (SC) or SC plus MMBV arms. JUNO's primary objective was to assess antibiotic prescription rate in the SC arm; the secondary objective was to assess JUPITER's study design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven centers randomized 260 patients, with 214 included (106 SC, 108\u2009MMBV). Median (IQR) age was 40 (28\u201355.8)\u2009years, 57% were female, and 78.5% were enrolled at ED. Common symptoms were cough (93.0%) and chills (70.0%). Overall, antibiotic prescription rates were 30% (95% CI 22% to 40%) and 24% (95% CI 17% to 33%) in the SC arm versus the MMBV (absolute difference of \u22126% [95% CI \u221218% to 6%]). More antibiotics were given with bacterial MMBV scores (41% vs. 78%, absolute difference 37%, 95% CI 6% to 61%; <jats:italic>n<\/jats:italic>\u2009=\u200940) and less with viral MMBV scores (25% vs. 12%, absolute difference \u201313%, 95% CI \u221225% to 0%; <jats:italic>n<\/jats:italic>\u2009=\u2009144) in the SC versus MMBV arms. There was no increase in ED\/UC return visits (8% vs. 3%, difference \u20136%, 95% CI \u221212% to 1%) or hospitalizations (3% vs. 0%, difference \u20133%, 95% CI \u22127% to 1%) in the SC arm versus the MMBV arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>JUNO demonstrated that JUPITER's design results in 30% antibiotic prescription rate in the SC arm. JUNO supports that MMBV optimizes antibiotic prescriptions without increasing return ED\/UC visits or hospitalizations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acem.70031","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T02:31:16Z","timestamp":1745029876000},"page":"975-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of host\u2010protein test (<scp>TRAIL<\/scp>\/<scp>IP<\/scp>\u201010\/<scp>CRP<\/scp>) on antibiotic prescription and emergency department or urgent care center return visits: The <scp>JUNO<\/scp> pilot randomized controlled trial"],"prefix":"10.1111","volume":"32","author":[{"given":"Adam J.","family":"Singer","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judd E.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College of Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat R.","family":"Kean","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College of Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Ring","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-6742","authenticated-orcid":false,"given":"W. Frank","family":"Peacock","sequence":"additional","affiliation":[{"name":"Emergency Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina M.","family":"Soto\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Emergency Medicine Comprehensive Research Associates, LLC  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Motov","sequence":"additional","affiliation":[{"name":"Emergency Medicine Maimonides Medical Center  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-3369","authenticated-orcid":false,"given":"Joby","family":"Thoppil","sequence":"additional","affiliation":[{"name":"Emergency Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Hendry","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Halabi","sequence":"additional","affiliation":[{"name":"Emergency Medicine Carmel Medical Center  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-8314","authenticated-orcid":false,"given":"Andrew C.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Emergency Medicine George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Headden","sequence":"additional","affiliation":[{"name":"Emergency Medicine The Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Brosh\u2010Nissimov","sequence":"additional","affiliation":[{"name":"Emergency Medicine Assuta Ashdod Medical Center  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zeltser","sequence":"additional","affiliation":[{"name":"Emergency Medicine Tel Aviv Sourasky Medical Center \u2010 Ichilov  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Kansas Medical Center  Kansas City Kansas 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