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The purpose of this study is to determine the prevalence of other psychological comorbidities and clinical factors associated with severe anxiety in LRCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline data is analyzed from the PACER trial comparing the effectiveness of two telehealth interventions for LRCP patients with anxiety. Key eligibility criteria are a HEART score &lt;\u20097 and either a GAD\u20107 anxiety score \u2265\u20098 or a positive PHQ screener for panic disorder. Psychological comorbidity measures included the Patient Health Questionnaire 8\u2010item (PHQ\u20108) depression scale, the PHQ\u201014 somatization scale, the Primary Care Posttraumatic Stress Disorder Screen, the Sheehan Disability Scale, and the General Self\u2010Efficacy Scale. Multivariable modeling is used to determine factors associated with severe anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 375 patients had a mean age of 39.9; 70.9% were women; 62.9% were White, 32.6% Black, and 4.5% other race. The majority (75%) screened positive for panic disorder, and 42% of participants had severe anxiety (GAD\u20107\u2009\u2265\u200915). Non\u2010anxiety psychological comorbidity was very high; the proportion of patients exceeding scale cut points was 58% for depression, 57% for PTSD, 52% for somatization, 59% for high disability, and 31% for low self\u2010efficacy; each was significantly associated with severe anxiety on univariable analysis. Four patient characteristics were independently associated with severe anxiety in multivariable models: odds ratios (95% CI) were 2.7 (1.5\u20134.9) for depression, 2.3 (1.4\u20133.9) for low self\u2010efficacy, 2.1 (1.2\u20133.6) for low education (high school or less), and 1.8 (1.0 to 3.3) for female sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LRCP is accompanied not only by anxiety but also by other potentially treatable psychological comorbidities Severe anxiety is more common in individuals with depression, low self\u2010efficacy, lower education, and possibly women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>\n                      PACER is registered in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      identifier: NCT04811521\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.70113","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T04:59:31Z","timestamp":1754715571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychological Comorbidity in Patients Presenting to the Emergency Department With Low\u2010Risk Chest Pain and Anxiety"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7744-2752","authenticated-orcid":false,"given":"Linh","family":"Dang","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana 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