{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:08:22Z","timestamp":1774422502133,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UG1DA01583"],"award-info":[{"award-number":["UG1DA01583"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>To characterize opioid and nonopioid drug use in the week following emergency department (ED)\u2010initiated extended\u2010release buprenorphine (XR\u2010BUP) treatment using both self\u2010reported data and urine drug screens (UDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study uses data collected during a nonrandomized clinical trial of patients with untreated opioid use disorder (OUD), testing the safety and feasibility of initiating XR\u2010BUP in patients presenting with minimal to mild withdrawal. The study was conducted from July 2020 to May 2023 across four urban academic EDs in the Northeast, Mid\u2010Atlantic, and Pacific regions of the United States. A total of 100 participants, 18\u2009years or older with OUD defined by DSM\u20105 criteria, a clinical opiate withdrawal scale (COWS &lt;\u20098), and a positive opioid urine screen were included. Individuals with recent MOUD treatment, presentation for overdose, or concurrent methadone use were excluded. All participants received a single subcutaneous injection of 24\u2009mg XR\u2010BUP (CAM2038) during their ED visit. The primary outcomes were self\u2010reported daily opioid and nonopioid drug use over 7\u2009days postinjection using daily Qualtrics surveys and UDS results on day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants who received XR\u2010BUP and completed daily surveys, 98% reported at least one opioid\u2010free day, and 63% reported no opioid use across all 7\u2009days. Day 7 UDS results showed decreased detection of opioids, stimulants, and benzodiazepines. Reported polysubstance use also declined over the observation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ED\u2010initiated XR\u2010BUP was associated with substantial reductions in opioid and polysubstance use during the first week post\u2010discharge, supporting its role in early overdose risk mitigation and highlighting its value as an ED\u2010based intervention for opioid use disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT03658642<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.70191","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:11:00Z","timestamp":1764047460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug Use After Emergency Department\u2010Initiated Injectable Buprenorphine: A Secondary Analysis of the\n                    <scp>ED<\/scp>\n                    \u2010\n                    <scp>INNOVATION<\/scp>\n                    Ancillary Safety and Feasibility Trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Ethan","family":"Cowan","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Health Policy and Management Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanmarie","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Highland General Hospital\u2010Alameda Health System  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Dziura","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Yale Center for Analytical Sciences (YCAS) Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Hawk","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Epidemiology and Chronic Disease School of Public Health, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Herring","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Highland General Hospital\u2010Alameda Health System  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"McCormack","sequence":"additional","affiliation":[{"name":"Ronald O. 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