{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:26:14Z","timestamp":1789518374089,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare the efficacy and safety of an initial 12\u2009mg versus 6\u2009mg adenosine dose for sinus rhythm conversion in patients presenting with supraventricular tachycardia (SVT) in the emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study was conducted between February 2025 and January 2026. Adult patients (\u2265\u200918\u2009years) presenting to the ED with hemodynamically stable SVT confirmed by 12\u2010lead electrocardiography (ECG) were included. Patients were categorized into two groups according to the initial adenosine dose administered (6\u2009mg vs. 12\u2009mg). To address potential selection bias, 1:1 propensity score matching (PSM) was performed. The primary outcome was successful first\u2010dose sinus rhythm conversion. Secondary outcomes included adenosine\u2010related adverse effects and SVT recurrence during the ED stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 142 patients were analyzed (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200971 per group). First\u2010dose conversion was significantly higher with 12\u2009mg compared with 6\u2009mg (83.1% vs. 52.1%). In the PSM cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104), the 12\u2009mg dose maintained its superior efficacy (82.7% vs. 53.8%). The PSM\u2010adjusted odds ratio for successful conversion was 4.12 (95% confidence interval [CI]: 1.85\u20139.14), with a number needed to treat (NNT) of 3.8 (95% CI: 2.5\u20138.3). SVT recurrence was numerically lower in the 12\u2009mg group (1.4% vs. 9.9%). Adverse effects were similar between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An initial 12\u2009mg adenosine dose was associated with higher first\u2010dose sinus rhythm conversion than 6\u2009mg, while adverse effects were similar between groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.70309","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:15:21Z","timestamp":1777522521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Initial 12\u2009mg Versus 6\u2009mg Adenosine for Supraventricular Tachycardia in the Emergency Department"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-2186","authenticated-orcid":false,"given":"Ekrem Taha","family":"Sert","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kokulu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"Y\u00fcr\u00fck","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin H\u00fcseyin","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Ali","family":"Topuz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-025-01288-8"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz467"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000311"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.01.035"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000001050"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.08.044"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2025.2504521"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61485-4"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2025.05.020"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2025.02.006"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"issue":"10","key":"e_1_2_14_14_1","article-title":"Adenosine Versus Intravenous Calcium Channel Antagonists for Supraventricular Tachycardia","volume":"10","author":"Alabed S.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2025.12.016"}],"container-title":["Academic Emergency 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