{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:46:00Z","timestamp":1792565160941,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Importance<\/jats:title>\n                    <jats:p>Early trauma\u2010induced coagulopathy (eTIC) is a major contributor to hemorrhage\u2010related mortality after severe trauma. Viscoelastic testing using thromboelastography (TEG) has been increasingly implemented in trauma resuscitation; however, its prognostic value compared with conventional coagulation testing remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated the ability of TEG parameters to detect eTIC, hypofibrinogenemia, and hyperfibrinolysis in severely injured trauma patients. In addition, we assessed their prognostic performance for transfusion requirements and mortality compared with conventional laboratory parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective single\u2010center cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Participants<\/jats:title>\n                    <jats:p>Severely injured adult trauma patients admitted to the resuscitation room of a Level I trauma center, between January 2019 and October 2024 were screened.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measures and Analysis<\/jats:title>\n                    <jats:p>Primary outcomes were detection of eTIC (INR &gt;\u20091.2), severe coagulopathy (INR &gt;\u20091.5), hypofibrinogenemia (&lt;\u2009200\u2009mg\/dL), and thrombocytopenia (&lt;\u2009100,000\/\u03bcL). Secondary outcomes included the ability of coagulation parameters to predict the need for transfusion of \u2265\u20095\u2009units of packed red blood cells within the first 24\u2009h after admission and in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 262 patients were included; median ISS was 29 (IQR 23\u201341), and in\u2010hospital mortality was 22.8%. eTIC was present in 31.5% of patients. TEG parameters showed moderate discriminatory performance for coagulopathy detection. For eTIC, maximum amplitude achieved an AUC of 0.73, while R\u2010time achieved an AUC of 0.65. Predictive performance improved for severe coagulopathy, with R\u2010time reaching an AUC of 0.81. Hyperfibrinolysis (LY30\u2009&gt;\u20097%) was uncommon (6.9%). Conventional laboratory parameters, particularly INR, consistently outperformed TEG\u2010derived parameters for prediction of transfusion requirements (AUC 0.85) and mortality (AUC 0.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In severely injured trauma patients, conventional coagulation testing, particularly INR, demonstrated superior prognostic performance compared with individual TEG parameters. Viscoelastic testing may provide complementary information but did not replace standard laboratory testing for prediction of transfusion needs or mortality in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT07186712\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acem.70423","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:18:22Z","timestamp":1792563502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Thromboelastography Parameters for Early Trauma\u2010Induced Coagulopathy in Severely Injured Patients: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-075X","authenticated-orcid":false,"given":"Gabriel","family":"Honnef","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-3193","authenticated-orcid":false,"given":"Philipp","family":"Zoidl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-9039","authenticated-orcid":false,"given":"Barbara","family":"Hallmann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical University of Graz  Graz 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