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In this study, we pharmacologically characterized the intermittent access to 20% ethanol (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>) model (<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ise,<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>sychopharmacologia<\/jats:italic>1973;29:203) in<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ardinian alcohol\u2010preferring (sP) rats to determine to which of the compounds known to reduce drinking in specific animal models this binge\u2010like drinking was sensitive to.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult male<jats:styled-content style=\"fixed-case\">sP<\/jats:styled-content>rats were divided into 2 groups and allowed to drink either 20% v\/v alcohol or water for 24\u00a0hours on alternate days (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>onday,<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ednesday, and<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>riday) or 10% v\/v alcohol and water for 24\u00a0hours every day. After stabilization of their intake, both groups were administered 3 pharmacological agents with different mechanisms of action, naltrexone\u2014an opioid receptor antagonist,<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>39166\u2014a dopamine<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>1 receptor antagonist, and<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>121919\u2014a Corticotropin\u2010Releasing Factor 1 (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>1<\/jats:sub>) receptor antagonist, and their effects on alcohol and water intake were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intermittent 20% alcohol (\u201c<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ise\u201d) procedure in s<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rats led to binge\u2010like drinking. Alcohol drinking was suppressed by naltrexone and by<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>39166, but not by<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>121919. Finally, naltrexone was more potent in reducing alcohol drinking in the intermittent 20% binge\u2010drinking group than in the 10% continuous access drinking group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ise procedure in s<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rats induces binge\u2010like drinking, which appears opioid\u2010 and dopamine\u2010receptor mediated; the<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>1<\/jats:sub>system, on the other hand, does not appear to be involved. In addition, our results suggest that naltrexone is particularly effective in reducing binge drinking. Such different pharmacological responses may apply to subtypes of alcoholic patients who differ in their motivation to drink, and may eventually contribute to treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12008","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T16:11:23Z","timestamp":1352131883000},"page":"635-643","source":"Crossref","is-referenced-by-count":50,"title":["Pharmacological Characterization of the 20% Alcohol Intermittent Access Model in<scp>S<\/scp>ardinian Alcohol\u2010Preferring Rats: A Model of Binge\u2010Like Drinking"],"prefix":"10.1111","volume":"37","author":[{"given":"Valentina","family":"Sabino","sequence":"first","affiliation":[{"name":"Laboratory of Addictive Disorders Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry Boston University School of Medicine Boston 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