{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:19:05Z","timestamp":1781187545436,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acamprosate has been found to enhance rates of complete abstinence and to increase percent days abstinent (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>) from alcohol relative to placebo treatment. As most <jats:styled-content style=\"fixed-case\">U.S.<\/jats:styled-content> clinical trials of acamprosate have been conducted in alcohol and other drug specialty clinics, there is a need to examine the efficacy of acamprosate in generalist settings. This study tested the efficacy of acamprosate versus placebo on the primary study outcome of <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> in the treatment of alcohol\u2010dependent patients in a family medicine setting. Secondary study outcomes included percent heavy drinking days (%<jats:styled-content style=\"fixed-case\">HDD<\/jats:styled-content>) and gamma glutamyltransferase level (normal or high).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled, parallel group design of acamprosate was conducted in 2 family medicine settings (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>arolina and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>isconsin). One hundred volunteers were recruited primarily by advertisement, and participants were assigned to 666\u00a0mg (2\u00a0pills) oral acamprosate 3 times daily (1,998\u00a0mg\/d) or matching placebo over a 12\u2010week period. All participants concomitantly received 5 sessions of a brief behavioral intervention from a family\/primary care physician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant treatment effect of acamprosate was found on <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> or the secondary outcomes. Significant treatment goal by time interaction effects was found on <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> and %<jats:styled-content style=\"fixed-case\">HDD<\/jats:styled-content>. Participants who had an initial goal of abstinence versus a reduction in alcohol use improved on average over time in <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> and had less %<jats:styled-content style=\"fixed-case\">HDD<\/jats:styled-content> from baseline to the end of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This clinical trial did not find evidence of efficacy for acamprosate compared to placebo among alcohol\u2010dependent individuals recruited primarily by advertisement as studied in a primary care setting. Drinking outcomes significantly improved regardless of medication condition. A goal of abstinence was significantly associated with improved drinking outcomes, suggesting that alcohol\u2010dependent patients with such a goal may do particularly well with counseling in a family medicine setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12010","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T15:51:54Z","timestamp":1352303514000},"page":"668-674","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of Acamprosate for Alcohol Dependence in a Family Medicine Setting in the <scp>U<\/scp>nited <scp>S<\/scp>tates: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Lisa","family":"Berger","sequence":"first","affiliation":[{"name":"Center for Addiction and Behavioral Health Research University of Wisconsin\u2010Milwaukee Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brondino","sequence":"additional","affiliation":[{"name":"Center for Addiction and Behavioral Health Research University of Wisconsin\u2010Milwaukee Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bohn","sequence":"additional","affiliation":[{"name":"Aurora Health Care Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gwyther","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Bowles Center for Alcohol Studies University of North Carolina at 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