{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:57:29Z","timestamp":1758970649150},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced central serotonergic neurotransmission has been demonstrated in individuals with excessive alcohol consumption and\/or alcohol dependence. Childhood maltreatment has also been found to have a negative impact on central serotonergic neurotransmission. The aim of this study was to evaluate the impact of childhood maltreatment on central serotonergic dysfunction in alcohol\u2010dependent individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult men with a diagnosis of alcohol dependence (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) were recruited from outpatient treatment units for alcoholism. Central serotonergic neurotransmission was assessed by a neuroendocrine method, that is, the prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>) response to the selective 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>reuptake inhibitor citalopram. Childhood maltreatment was assessed retrospectively by the<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildhood<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rauma<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol\u2010dependent individuals with childhood experience of emotional abuse had significantly lower<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>response compared with those without such abuse (3\u00a0\u00b1\u00a05 and 64\u00a0\u00b1\u00a024\u00a0mU\/l, respectively;<jats:italic>t\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6.51,<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Among those who reported childhood emotional abuse, 4 of 7 individuals had flat<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>responses in comparison with none in those with no report of such abuse (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to show that self\u2010reported childhood maltreatment, in particular emotional abuse, in male alcohol\u2010dependent individuals is associated with a quite dramatic (more than 90%) reduction in central serotonergic neurotransmission. It should, however, be noted that the number of individuals is relatively small, and the results should therefore be considered as preliminary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12023","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T15:52:11Z","timestamp":1360079531000},"page":"757-762","source":"Crossref","is-referenced-by-count":23,"title":["Childhood Maltreatment Affects the Serotonergic System in Male Alcohol\u2010Dependent Individuals"],"prefix":"10.1111","volume":"37","author":[{"given":"Kristina J.","family":"Berglund","sequence":"first","affiliation":[{"name":"Department of Psychology University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Balldin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry the Institute of Neuroscience and Physiology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Berggren","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry the Institute of Neuroscience and Physiology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Gerdner","sequence":"additional","affiliation":[{"name":"School of Health Sciences J\u00f6nk\u00f6ping University J\u00f6nk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fahlke","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02269.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00045.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780020114013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249132"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(01)00154-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039480802095523"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0412-3"},{"key":"e_1_2_6_10_1","volume-title":"Childhood Trauma Questionnaire. 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