{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:44:58Z","timestamp":1698738298849},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thiamine deficiency in patients who abuse alcohol can cause <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ernicke's encephalopathy (<jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content>). Thiamine supplements are given to prevent this complication. Guidelines exist for giving thiamine supplementation in the inpatient population. However, similar guidelines are not available for clinicians detoxifying patients in the community, and consequently, assessment of risk of <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> and prophylaxis can be inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A scoring system to assess risk of <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> was developed and evaluated by comparing practice before and after introduction of the system. One hundred and twenty\u2010six cases requiring alcohol detoxification were examined: 94 before introduction of the scoring system and 32 afterward.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before introduction of the scoring system, a risk assessment for developing <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> was performed in 30% of patients and parenteral thiamine prescribed in 32%. After introduction of the scoring system, risk assessment and administration of parenteral thiamine increased to 100 and 75%, respectively. There was 1 probable case of <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> before introduction of the scoring system and none afterward.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that assessment of <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> is often inadequate, leading to inadequate thiamine administration. The new scoring system allows simple, structured risk assessment for <jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content> and thus guides appropriate thiamine administration. This is of most value to clinicians treating the consequences of alcohol dependence in the community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12028","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T04:05:03Z","timestamp":1356149103000},"page":"885-889","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Scoring System to Guide Risk Assessment of <scp>W<\/scp>ernicke's Encephalopathy"],"prefix":"10.1111","volume":"37","author":[{"given":"Amy","family":"Green","sequence":"first","affiliation":[{"name":"Bristol Specialist Drugs and Alcohol Service Colston Fort Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Parker","sequence":"additional","affiliation":[{"name":"NIHR Centre for Liver Research and Biomedical Research Unit University of Birmingham Edgbaston Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Bristol Specialist Drug and Alcohol Service Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.51"},{"key":"e_1_2_6_3_1","first-page":"CD004033","article-title":"Thiamine for Wernicke\u2010Korsakoff Syndrome in people at risk from alcohol abuse","volume":"1","author":"Day E","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03153.x"},{"key":"e_1_2_6_5_1","volume-title":"Alcohol\u2014Can the NHS Afford It","author":"Gilmore I","year":"2001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832941"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595238280000481"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.2.282"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.4.341"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)05980-7"},{"key":"e_1_2_6_11_1","unstructured":"IAS(2010)Institute of Alcohol Studies factsheet: Alcohol consumption. 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