{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:54:50Z","timestamp":1789707290133,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Individuals who report problematic drinking early in life often recover from alcohol\u2010related disorders, with or without formal treatment. While risk factors associated with developing alcohol use disorders (\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      s), such as a family history of alcoholism and the genetically influenced low level of response (\n                      <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\n                      ) to alcohol, have been identified, less is known about characteristics that relate to remission from\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The male subjects (98%\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      aucasian) for this study were 129 probands from the\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      an\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      iego\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      rospective\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy who were first evaluated at age 20 as drinking but not alcohol\u2010dependent young men, most of whom were college graduates by follow\u2010up. The individuals evaluated here met criteria for an\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      at their first follow\u2010up at ages 28 to 33 and were followed every 5\u00a0years for the next 2 decades. Discrete\u2010time survival analysis was used to examine rates of initial and sustained\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      remission and to evaluate the relationships of premorbid characteristics and other risk factors to these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty percent of the sample met criteria for an initial\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      remission of 5 or more years, including 45% with sustained remission (i.e., no subsequent\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      diagnosis). Higher education, lower drinking frequency, and having a diagnosis of alcohol abuse (rather than dependence) were associated with higher rates of initial\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      remission. A lower\n                      <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\n                      to alcohol at age 20, as well as lower drinking frequency, having received formal alcohol treatment, and older age at the first follow\u2010up all predicted a greater likelihood of sustained\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study identified key factors associated with initial and sustained\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      remission in subjects diagnosed with\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      in young adulthood. Characteristics associated with better outcomes early in the life span, such as lower drinking frequency and early treatment, appear to have a lasting impact on remission from\n                      <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>\n                      across adulthood.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.12107","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:36:25Z","timestamp":1362443785000},"page":"1424-1431","source":"Crossref","is-referenced-by-count":40,"title":["Predictors of Initial and Sustained Remission from Alcohol Use Disorders: Findings from the 30\u2010Year Follow\u2010Up of the\n                    <scp>S<\/scp>\n                    an\n                    <scp>D<\/scp>\n                    iego Prospective Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Ryan S.","family":"Trim","sequence":"first","affiliation":[{"name":"VA San 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