{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:36:27Z","timestamp":1790980587183,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Since its advent, alcohol has been utilized throughout history socially, for rituals, worship, and for its therapeutic, antibacterial, and analgesic properties. In moderation, alcohol consumption and its use are generally viewed as clinically beneficial. Excessive alcohol consumption on the other hand has been recognized as having several adverse implications. Excessive use increases the risk of liver and heart disease, metabolic disturbances, nutritional deficiencies, certain cancers, brain damage, dementia, neuropathy, as well as other facets of morbidity and mortality. This review targets the sequelae of alcohol consumption on the heart, specifically on myocardial contractility, calcium channel signaling, and intracellular signaling pathways. With the incidence of alcohol\u2010induced cardiac abnormalities being higher than previously thought, it is of increasing importance to elucidate the mechanisms behind them. Here, the cardiac effects of alcohol were not discussed in isolation but in conjunction with other important factors, such as high\u2010 and low\u2010density lipoprotein levels and vascular dilatory influences. We explore these mechanisms, in particular, the oxidative stress as the major contributor, as well as pathways that may prove to be cardioprotective. As such, we demonstrate the involvement of nuclear factor (erythroid\u2010derived 2)\u2010like 2 (<jats:styled-content style=\"fixed-case\">NFE<\/jats:styled-content>2L2\/<jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>2) as well as AKT that act as regulators of oxidative balance during oxidative stress responses. Thus, alcohol consumption may confer a cardioprotective effect when used in moderation through an AKT\/<jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>2\u2010dependent mechanism.<\/jats:p>","DOI":"10.1111\/acer.12109","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T16:09:12Z","timestamp":1364227752000},"page":"1253-1260","source":"Crossref","is-referenced-by-count":68,"title":["The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart"],"prefix":"10.1111","volume":"37","author":[{"given":"Robin K.","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Physiology &amp; Biophysics College of Medicine, Howard University Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie M.","family":"Cousins","sequence":"additional","affiliation":[{"name":"Department of Physiology &amp; Biophysics College of Medicine, Howard University Washington District of 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