{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:16Z","timestamp":1791298336357,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, procedures have been developed to model specific facets of human alcohol abuse disorders, including those that model excessive binge\u2010like drinking (i.e., \u201cdrinking\u2010in\u2010the\u2010dark,\u201d or<jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>procedures) and excessive dependence\u2010like drinking (i.e., intermittent ethanol [<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>] vapor exposure). Similar neuropeptide systems modulate excessive<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking stemming from both procedures, raising the possibility that both paradigms are actually modeling the same phenotypes and triggering the same central neuroplasticity. Therefore, the goal of this present project was to study the effects of a history of binge\u2010like<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking, using<jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>procedures, on phenotypes that have previously been described with procedures to model dependence\u2010like drinking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>mice first experienced 0 to 10 four\u2010day binge\u2010like drinking episodes (3\u00a0days of rest between episodes). Beginning 24\u00a0hours after the final binge\u2010like drinking session, mice were tested for anxiety\u2010like behaviors (with elevated plus maze [<jats:styled-content style=\"fixed-case\">EPM<\/jats:styled-content>] and open\u2010field locomotor activity tests), ataxia with the rotarod test, and sensitivity to handling\u2010induced convulsions (<jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>s). One week later, mice began a 40\u2010day 2\u2010bottle (water vs.<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>) voluntary consumption test with concentration ranging from 10 to 20% (v\/v)<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A prior history of binge\u2010like<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking significantly increased subsequent voluntary<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>consumption and preference, effects most robust in groups that initially experienced 6 or 10 binge\u2010like drinking episodes and completely absent in mice that experienced 1 binge\u2010like drinking episode. Conversely, a history of binge\u2010like<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking did not influence anxiety\u2010like behaviors, ataxia, or<jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Excessive<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking stemming from<jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>procedures does not initially induce phenotypes consistent with a dependence\u2010like state. However, the subsequent increases in voluntary<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>consumption and preference that become more robust following repeated episodes of binge\u2010like<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>drinking may reflect the early stages of<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dependence, suggesting that<jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>procedures may be ideal for studying the transition to<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>t<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dependence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12145","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T19:49:58Z","timestamp":1367610598000},"page":"1688-1695","source":"Crossref","is-referenced-by-count":73,"title":["Repeated Cycles of Binge\u2010Like Ethanol (<scp>E<\/scp>t<scp>OH<\/scp>)\u2010Drinking in Male<scp>C<\/scp>57<scp>BL<\/scp>\/6<scp>J<\/scp>Mice Augments Subsequent Voluntary<scp>E<\/scp>t<scp>OH<\/scp>Intake But Not Other Dependence\u2010Like Phenotypes"],"prefix":"10.1111","volume":"37","author":[{"given":"Benjamin R.","family":"Cox","sequence":"first","affiliation":[{"name":"Department of Psychology University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Olney","sequence":"additional","affiliation":[{"name":"Department of Psychology University of North Carolina Chapel Hill North 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