{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:58:31Z","timestamp":1771808311648,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp; Exp Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Background<\/jats:title>Combined iron overload and alcohol may promote synergistic chronic liver injury and toxicity. The role of specific dietary fats in influencing the development of co\u2010toxic alcoholic liver disease needs further evaluation and is investigated in this study.<\/jats:p><\/jats:sec>Methods<\/jats:title>Wild\u2010type (WT<\/jats:styled-content>) and the iron\u2010loaded H<\/jats:styled-content>fe\u2010null (H<\/jats:styled-content>fe<\/jats:italic>\u2212<\/jats:italic>\/\u2212<\/jats:italic><\/jats:sup>) mice were fed chow (CC<\/jats:styled-content>), a AIN<\/jats:styled-content>\u201093G<\/jats:styled-content> standard control (SC<\/jats:styled-content>), or a corn oil\u2013modified, AIN<\/jats:styled-content>\u201093G<\/jats:styled-content>\u2010based (CO<\/jats:styled-content>) diet with or without the addition of 20% ethanol (EtOH) in the drinking water for 8\u00a0weeks and assessed for liver injury.<\/jats:p><\/jats:sec>Results<\/jats:title>WT mice on CC<\/jats:styled-content>, SC<\/jats:styled-content>, and CO<\/jats:styled-content> diets had no liver injury, although mild steatosis developed in the SC<\/jats:styled-content> and CO<\/jats:styled-content> groups. The addition of EtOH resulted in mild steatohepatitis in WT<\/jats:styled-content> mice fed SC<\/jats:styled-content> but not those on a CO<\/jats:styled-content> diet. EtOH administration in H<\/jats:styled-content>fe<\/jats:italic>\u2212<\/jats:italic>\/\u2212<\/jats:italic><\/jats:sup> animals on the CC<\/jats:styled-content> and SC<\/jats:styled-content> diets caused marked oxidative stress, inflammatory activity, and subsinusoidal and portal\u2013portal tract linkage fibrosis with significant up\u2010regulation of genes involved in cellular stress signaling and fibrogenic pathways. These effects were abrogated in the CO<\/jats:styled-content>\u2010fed mice, despite elevated serum EtOH levels and hepatic iron concentrations, reduced hepatic glutathione and mitochondrial superoxide dismutase activities. Feeding with the CO<\/jats:styled-content> diet led to increased hepatic glutathione peroxidase and catalase activities and attenuated alcohol\u2010induced hepatic steatosis in the H<\/jats:styled-content>fe<\/jats:italic>\u2212<\/jats:italic>\/\u2212<\/jats:italic><\/jats:sup> animals. Iron and EtOH feeding markedly reduced p\u2010STAT<\/jats:styled-content>3 and p\u2010AMPK<\/jats:styled-content> protein levels, but this effect was significantly attenuated when a CO<\/jats:styled-content> diet was consumed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A CO<\/jats:styled-content>\u2010based diet is protective against combined EtOH\u2010 and iron\u2010induced liver toxicity, likely via attenuation of hepatic steatosis and oxidative stress and may have a role in the prevention of fibrosis development in chronic liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12155","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T16:33:58Z","timestamp":1370536438000},"page":"1619-1631","source":"Crossref","is-referenced-by-count":7,"title":["A Corn Oil\u2013Based Diet Protects Against Combined Ethanol and Iron\u2010Induced Liver Injury in a Mouse Model of Hemochromatosis"],"prefix":"10.1111","volume":"37","author":[{"given":"Terrence C. 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