{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:55Z","timestamp":1777425355123,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":594,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol Clin Exp Res"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1111\/acer.12259","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T17:10:07Z","timestamp":1389805807000},"page":"529-537","source":"Crossref","is-referenced-by-count":18,"title":["Administration of Memantine During Withdrawal Mitigates Overactivity and Spatial Learning Impairments Associated with Neonatal Alcohol Exposure in Rats"],"prefix":"10.1111","volume":"38","author":[{"given":"Nirelia M.","family":"Idrus","sequence":"first","affiliation":[{"name":"Center for Behavioral Teratology; Department of Psychology; San Diego State University; San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy N. H.","family":"McGough","sequence":"additional","affiliation":[{"name":"Center for Behavioral Teratology; Department of Psychology; San Diego State University; San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward P.","family":"Riley","sequence":"additional","affiliation":[{"name":"Center for Behavioral Teratology; Department of Psychology; San Diego State University; San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Center for Behavioral Teratology; Department of Psychology; San Diego State University; San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"10.1111\/acer.12259-BIB0001|acer12259-cit-0001","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0197-0186(02)00046-3","article-title":"Ethanol sensitivity of NMDA receptors","volume":"41","author":"Allgaier","year":"2002","journal-title":"Neurochem Int"},{"key":"10.1111\/acer.12259-BIB0002|acer12259-cit-0002","doi-asserted-by":"crossref","first-page":"C1411","DOI":"10.1152\/ajpcell.00529.2008","article-title":"The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis","volume":"296","author":"Arndt","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1111\/acer.12259-BIB0003|acer12259-cit-0003","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.nlm.2005.08.010","article-title":"The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage","volume":"85","author":"Bardgett","year":"2006","journal-title":"Neurobiol Learn Mem"},{"key":"10.1111\/acer.12259-BIB0004|acer12259-cit-0004","doi-asserted-by":"crossref","first-page":"RRN1291","DOI":"10.1371\/currents.RRN1291","article-title":"Pharmacokinetics of memantine in rats and mice","volume":"3","author":"Beconi","year":"2011","journal-title":"PLoS Curr"},{"key":"10.1111\/acer.12259-BIB0005|acer12259-cit-0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0006|acer12259-cit-0006","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1530-0277.2000.tb02043.x","article-title":"A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels","volume":"24","author":"Costa","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0007|acer12259-cit-0007","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"10.1111\/acer.12259-BIB0008|acer12259-cit-0008","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1037\/0735-7044.119.5.1339","article-title":"Bright light suppresses hyperactivity induced by excitotoxic dorsal hippocampus lesions in the rat","volume":"119","author":"Godsil","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1111\/acer.12259-BIB0009|acer12259-cit-0009","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0892-0362(97)00062-7","article-title":"Neonatal binge ethanol exposure using intubation: timing and dose effects on place learning","volume":"19","author":"Goodlett","year":"1997","journal-title":"Neurotoxicol Teratol"},{"key":"10.1111\/acer.12259-BIB0010|acer12259-cit-0010","first-page":"61","article-title":"The role of the NMDA receptor in ethanol withdrawal","volume":"71","author":"Hoffman","year":"1994","journal-title":"EXS"},{"key":"10.1111\/acer.12259-BIB0011|acer12259-cit-0011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2202-8-81","article-title":"Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line","volume":"8","author":"Hong","year":"2007","journal-title":"BMC Neurosci"},{"key":"10.1111\/acer.12259-BIB0012|acer12259-cit-0012","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1097\/01.ALC.0000099029.55026.C6","article-title":"Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil","volume":"27","author":"Honse","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0013|acer12259-cit-0013","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1111\/acer.12259-BIB0014|acer12259-cit-0014","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1530-0277.2010.01351.x","article-title":"Administration of memantine during ethanol withdrawal in neonatal rats: effects on long-term ethanol-induced motor incoordination and cerebellar Purkinje cell loss","volume":"35","author":"Idrus","year":"2011a","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0015|acer12259-cit-0015","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ntt.2011.04.004","article-title":"The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats","volume":"33","author":"Idrus","year":"2011b","journal-title":"Neurotoxicol Teratol"},{"key":"10.1111\/acer.12259-BIB0016|acer12259-cit-0016","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"key":"10.1111\/acer.12259-BIB0017|acer12259-cit-0017","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1523\/JNEUROSCI.09-08-02809.1989","article-title":"Sensitivity of the developing rat brain to hypobaric\/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity","volume":"9","author":"Ikonomidou","year":"1989","journal-title":"J Neurosci"},{"key":"10.1111\/acer.12259-BIB0018|acer12259-cit-0018","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1111\/acer.12259-BIB0019|acer12259-cit-0019","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1526-4637.2010.00808.x","article-title":"Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial","volume":"11","author":"Keynan","year":"2010","journal-title":"Pain Med"},{"key":"10.1111\/acer.12259-BIB0020|acer12259-cit-0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0166-4328(01)00442-9","article-title":"Effect of excitotoxic lesions of rat medial prefrontal cortex on spatial memory","volume":"133","author":"Lacroix","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1111\/acer.12259-BIB0021|acer12259-cit-0021","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pbb.2007.07.012","article-title":"Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure","volume":"88","author":"Lewis","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1111\/acer.12259-BIB0022|acer12259-cit-0022","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0892-0362(03)00030-8","article-title":"Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus","volume":"25","author":"Livy","year":"2003","journal-title":"Neurotoxicol Teratol"},{"key":"10.1111\/acer.12259-BIB0023|acer12259-cit-0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(01)02037-7","article-title":"Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol","volume":"309","author":"Lukoyanov","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1111\/acer.12259-BIB0024|acer12259-cit-0024","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1523\/JNEUROSCI.1702-08.2008","article-title":"NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia","volume":"28","author":"Manning","year":"2008","journal-title":"J Neurosci"},{"key":"10.1111\/acer.12259-BIB0025|acer12259-cit-0025","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/01.ALC.0000156086.65665.4D","article-title":"Ethanol exposure decreases glutamate uptake in the nucleus accumbens","volume":"29","author":"Melendez","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0026|acer12259-cit-0026","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1747-597X-3-20","article-title":"Treatment of alcohol dependence in patients with co-morbid major depressive disorder-predictors for the outcomes with memantine and escitalopram medication","volume":"3","author":"Muhonen","year":"2008","journal-title":"Subst Abuse Treat Prev Policy"},{"key":"10.1111\/acer.12259-BIB0027|acer12259-cit-0027","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/01.ALC.0000106311.88523.7B","article-title":"NMDA receptor subunit expression after combined prenatal and postnatal exposure to ethanol","volume":"28","author":"Nixon","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0028|acer12259-cit-0028","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11065-011-9164-z","article-title":"Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder","volume":"21","author":"O'Leary-Moore","year":"2011","journal-title":"Neuropsychol Rev"},{"key":"10.1111\/acer.12259-BIB0029|acer12259-cit-0029","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/0028-3908(93)90029-3","article-title":"Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)","volume":"32","author":"Parsons","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1111\/acer.12259-BIB0030|acer12259-cit-0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neuropharm.2007.07.013","article-title":"Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse","volume":"53","author":"Parsons","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1111\/acer.12259-BIB0031|acer12259-cit-0031","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/157015908783769671","article-title":"Pharmacodynamics of memantine: an update","volume":"6","author":"Rammes","year":"2008","journal-title":"Curr Neuropharmacol"},{"key":"10.1111\/acer.12259-BIB0032|acer12259-cit-0032","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(01)02617-8","article-title":"Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats","volume":"911","author":"Rao","year":"2001","journal-title":"Brain Res"},{"key":"10.1111\/acer.12259-BIB0033|acer12259-cit-0033","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/bdra.20506","article-title":"Teratology: from science to birth defects prevention","volume":"85","author":"Rasmussen","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1111\/acer.12259-BIB0034|acer12259-cit-0034","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1530-0277.1986.tb05613.x","article-title":"The effects of physostigmine on open-field behavior in rats exposed to alcohol prenatally","volume":"10","author":"Riley","year":"1986","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0035|acer12259-cit-0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/15353702-0323006-03","article-title":"Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior","volume":"230","author":"Riley","year":"2005","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1111\/acer.12259-BIB0036|acer12259-cit-0036","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1528-1157.2000.tb00265.x","article-title":"Re: Mazarati et\u00a0al. \u201c\u2026clinically available [antiepileptic drug] with a moderate affinity for the glycine site of the N-methyl-D-aspartate (NMDA) receptor\u201d","volume":"41","author":"Rogawski","year":"2000","journal-title":"Epilepsia"},{"key":"10.1111\/acer.12259-BIB0037|acer12259-cit-0037","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00008877-199212000-00006","article-title":"NMDA antagonists disrupt timing behaviour in rats","volume":"3","author":"Sanger","year":"1992","journal-title":"Behav Pharmacol"},{"key":"10.1111\/acer.12259-BIB0038|acer12259-cit-0038","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11065-011-9168-8","article-title":"The effects of prenatal alcohol exposure on behavior: rodent and primate studies","volume":"21","author":"Schneider","year":"2011","journal-title":"Neuropsychol Rev"},{"key":"10.1111\/acer.12259-BIB0039|acer12259-cit-0039","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biopha.2008.02.005","article-title":"Current approaches in the treatment of Alzheimer's disease","volume":"62","author":"Shah","year":"2008","journal-title":"Biomed Pharmacother"},{"key":"10.1111\/acer.12259-BIB0040|acer12259-cit-0040","article-title":"The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study","author":"Shopsin","journal-title":"Acta Neuropsychiatr [Epub ahead of print]"},{"key":"10.1111\/acer.12259-BIB0041|acer12259-cit-0041","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0892-0362(99)00059-8","article-title":"Chronic ethanol exposure during late gestation produces behavioral anomalies in neonatal lambs","volume":"22","author":"Spear-Smith","year":"2000","journal-title":"Neurotoxicol Teratol"},{"key":"10.1111\/acer.12259-BIB0042|acer12259-cit-0042","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/j.1530-0277.2008.00801.x","article-title":"Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine","volume":"32","author":"Stepanyan","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0043|acer12259-cit-0043","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0165-0173(99)00048-X","article-title":"Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs","volume":"31","author":"Svensson","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1111\/acer.12259-BIB0044|acer12259-cit-0044","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-3806(01)00199-7","article-title":"A persistent deficit of serotonin neurons in the offspring of ethanol-fed dams: protective effects of maternal ipsapirone treatment","volume":"129","author":"Tajuddin","year":"2001","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1111\/acer.12259-BIB0045|acer12259-cit-0045","first-page":"134A","article-title":"MK-801 administration during withdrawal attenuates hippocampal CA1 pyramidal cell loss in rats neonatally exposed to alcohol","volume":"26","author":"Thomas","year":"2002a","journal-title":"Alcohol"},{"key":"10.1111\/acer.12259-BIB0046|acer12259-cit-0046","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1530-0277.2001.tb02277.x","article-title":"MK-801 can exacerbate or attenuate behavioral alterations associated with neonatal alcohol exposure in the rat, depending on the timing of administration","volume":"25","author":"Thomas","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0047|acer12259-cit-0047","first-page":"1307","article-title":"Administration of low doses of MK-801 during ethanol withdrawal in the developing rat pup attenuates alcohol's teratogenic effects","volume":"26","author":"Thomas","year":"2002b","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0048|acer12259-cit-0048","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00213-004-1806-x","article-title":"Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits","volume":"175","author":"Thomas","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1111\/acer.12259-BIB0049|acer12259-cit-0049","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/j.1530-0277.1997.tb04441.x","article-title":"MK-801 administration during ethanol withdrawal in neonatal rat pups attenuates ethanol-induced behavioral deficits","volume":"21","author":"Thomas","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0050|acer12259-cit-0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.med.49.1.173","article-title":"The role of glutamatergic neurotransmission in the pathophysiology of alcoholism","volume":"49","author":"Tsai","year":"1998","journal-title":"Annu Rev Med"},{"key":"10.1111\/acer.12259-BIB0051|acer12259-cit-0051","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0893-133X(00)00150-0","article-title":"WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801","volume":"23","author":"Wedzony","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1111\/acer.12259-BIB0052|acer12259-cit-0052","first-page":"1243","article-title":"Distribution of memantine in brain, liver, and blood of the rat","volume":"32","author":"Wesemann","year":"1982","journal-title":"Arzneimittelforschung"},{"key":"10.1111\/acer.12259-BIB0053|acer12259-cit-0053","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1530-0277.1990.tb01820.x","article-title":"Cell population depletion associated with fetal alcohol brain damage: mechanisms of BAC-dependent cell loss","volume":"14","author":"West","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12259-BIB0054|acer12259-cit-0054","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-130395","article-title":"Effectiveness and safety of memantine treatment for Alzheimer's disease","volume":"36","author":"Yang","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.1111\/acer.12259-BIB0055|acer12259-cit-0055","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.neuroscience.2006.05.011","article-title":"Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons","volume":"141","author":"Zhu","year":"2006","journal-title":"Neuroscience"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.12259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/acer.12259\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T16:51:12Z","timestamp":1625503872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.12259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"URL":"https:\/\/doi.org\/10.1111\/acer.12259","relation":{},"ISSN":["0145-6008"],"issn-type":[{"value":"0145-6008","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1,15]]}}}