{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:46:13Z","timestamp":1775911573562,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol is a risk factor for hypertension. Facial flushing after drinking is a typical symptom of high alcohol sensitivity. This study assessed the role of the facial flushing response in the relationship between alcohol consumption and hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 1,763 men (288 nondrinkers, 527 flushing drinkers, 948 nonflushing drinkers) who had received a health checkup. Data were collected from the subjects' medical records. The risk of hypertension related to weekly drinking amount in nonflushers and flushers was analyzed and compared with that in nondrinkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for age, body mass index, exercise status, and smoking status, the risk of hypertension was significantly increased when flushers consumed more than 4 drinks per week (more than 4 and up to 8 drinks: odds ratio [OR]\u00a0=\u00a02.23; above 8 drinks: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.35). In contrast, in nonflushers, the risk was increased with alcohol consumption of more than 8 drinks (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.61) per week. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> (flushers\/nonflushers) for hypertension was also increased: more than 4 and up to 8 drinks, 2.27 and above 8 drinks, 1.52.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that hypertension associated with alcohol consumption has a lower threshold value and higher risk in flushers than in nonflushers. Clinicians should consider evaluating patients' flushing response as well as drinking amount in a daily practice for health promotion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12302","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T15:37:51Z","timestamp":1384961871000},"page":"1020-1025","source":"Crossref","is-referenced-by-count":25,"title":["Hypertension Associated with Alcohol Consumption Based on the Facial Flushing Reaction to Drinking"],"prefix":"10.1111","volume":"38","author":[{"given":"Jin\u2010Gyu","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Family Medicine Research Institute for Medical Sciences School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Research Institute for Medical Sciences School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Research Institute for Medical Sciences School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Kyeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Departments of Family Medicine College of Medicine University of Ulsan Gangneung Asan Hospital Gangneung Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok\u2010Joon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Research Institute for Medical Sciences School of Medicine Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"93","article-title":"Racial differences in alcohol sensitivity","volume":"21","author":"Chan AW","year":"1986","journal-title":"Alcohol Alcohol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_5_4_1","first-page":"22","article-title":"ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review","volume":"30","author":"Eng MY","year":"2007","journal-title":"Alcohol Res Health"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1242"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91172-7"},{"key":"e_1_2_5_7_1","first-page":"8","article-title":"Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication","volume":"32","author":"Harada S","year":"1980","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_8_1","unstructured":"Korean Ministry Health and Welfare & Korea Centers for Disease Control and Prevention(2010)Korean National Health and Nutrition Examination Survey 2010. Percentage of drinkers. Available at:http:\/\/www.bokjiro.go.kr\/data\/statusView.do? board_sid=297&data_sid=5771475 [update 2011]. Accessed December 24 2012."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02632.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200105000-00003"},{"key":"e_1_2_5_11_1","unstructured":"NIAAA(2010)Drinking statistics. How many American adults (ages 18 and over) drank in the past year and how much did they drink?[update 2010]. Available at:http:\/\/www.niaaa.nih.gov\/alcohol-health\/overview-alcohol\u2010 consumption\/drinking\u2010statistics. 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