{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:12Z","timestamp":1789724112590,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Detection of in\u2010pregnancy maternal risk alcohol drinking is an essential first step in preventing fetal alcohol spectrum disorders, and the widely used T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> screen was developed for that purpose. We recently reported that increasing the total T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> score cut\u2010point from 2 to 3 doubled specificity of detecting risk drinking in pregnancy and identified 4\u2010year\u2010old children with neurobehavioral effects associated with prenatal alcohol exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, the <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103 was further validated in another prospectively identified high\u2010risk urban cohort. Women were categorized as follows: (i) Not At\u2010Risk Group (negative on T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103); (ii) At\u2010Risk Group (positive on T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103); and (iii) Change Risk Group (positive on T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> but negative on <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103 total score cut\u2010point of 3 yielded fewer \u201cfalse positives\u201d than the T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> cut\u2010point of 2. Based on relative risk scores, women in the <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103\u2010positive At\u2010Risk Group were more likely to drink alcohol during pregnancy than women in the Change Risk Group. In contrast, women in the Not At\u2010Risk Group were largely not different in their drinking from women in the Change Risk Group. The largest increases in relative risk of the At\u2010Risk Group compared to the Change Risk Group were for the amount of drinking per day across pregnancy (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a011.4) and for the amount of drinking per drinking day at the first prenatal visit (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a012.7). For both of these measures, the relative risk of at\u2010risk alcohol consumption in the At\u2010Risk Group was over &gt;10 times that of the Change Risk Group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thus, the <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103 was more effective at selectively identifying women drinking at fetal risk levels than the original T\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">TACER<\/jats:styled-content>\u20103 allows for more efficient use of healthcare provider time in directing targeted clinical interventions with pregnant women identified as drinking at fetal risk levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12368","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T16:23:29Z","timestamp":1395419009000},"page":"1401-1408","source":"Crossref","is-referenced-by-count":20,"title":["Increased Cut\u2010Point of the TACER\u20103 Screen Reduces False Positives Without Losing Sensitivity in Predicting Risk Alcohol Drinking in Pregnancy"],"prefix":"10.1111","volume":"38","author":[{"given":"Lisa M.","family":"Chiodo","sequence":"first","affiliation":[{"name":"College of Nursing Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Delaney\u2010Black","sequence":"additional","affiliation":[{"name":"Carman and Ann Adams Department of Pediatrics Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Sokol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Wayne State University Detroit Michigan"},{"name":"The C.S. Mott Center for Human Growth &amp; Development Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Janisse","sequence":"additional","affiliation":[{"name":"Department of Family Medicine &amp; Public Health Sciences Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yobany","family":"Pardo","sequence":"additional","affiliation":[{"name":"Women's Center St Joseph Mercy Oakland Pontiac Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hannigan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Wayne State University Detroit Michigan"},{"name":"The C.S. 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